摘要
目的探讨补中益气汤联合FOLFIRI方案化疗治疗结直肠癌的效果。方法选择2016年1月至2020年1月在我院诊治的结直肠癌患者80例,按治疗方案的不同分为两组。对照组行FOLFIRI方案化疗,观察组则在前者治疗方案中联合补中益气汤治疗。观察并分析两组治疗前后免疫功能指标、炎症因子水平变化以及血常规、肝肾功能变化情况,治疗后临床疗效、生活质量评分情况。结果观察组总有效率明显高于对照组(P<0.05);治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平较治疗前均有所升高,且观察组升高程度高于对照组(P<0.05);治疗后,两组血浆淀粉样蛋白(SAA)、C反应蛋白(CRP)较治疗前有所升高,且观察组升高程度低于对照组(P<0.05);治疗后,两组血小板计数及白细胞计数较治疗前均有所降低,且观察组下降幅度低于对照组(P<0.05);两组治疗前后肝功能无明显变化(P>0.05)。治疗后,两组血肌酐水平较治疗前有所降低,且观察组明显低于对照组(P<0.05);治疗后,两组生活质量均有一定改善,且观察组明显高于对照组(P<0.05);治疗后,观察组不良反应发生率低于对照组(P<0.05)。结论FOLFIRI方案化疗在结直肠癌患者中有良好的治疗效果,配合补中益气汤,能够进一步改善患者免疫功能,降低炎症反应,提高其生活质量,减少不良反应,是一种安全、有效、可行的治疗方案。
Objective To analyze the application effect of Buzhong Yiqi Decoction Combined with FOLFIRI chemotherapy in the treatment of colorectal cancer.Methods 80 patients with colorectal cancer in our hospital from January 2016 to January 2020 were selected and divided into two groups according to different treatment schemes.The control group was treated with FOLFIRI chemotherapy,while the observation group was treated with Buzhong Yiqi Decoction.Immune function index,inflammatory factor level,blood routine,liver and kidney function,clinical efficacy and quality of life score between groups before and after treatment were observed and analyzed.Results After treatment,total effective rate was significantly higher in observation group than in control group(P<0.05);significantly higher CD3^(+),CD4^(+),CD4^(+)/CD8^(+) level were detected in groups and increase degree in observation group was even higher(P<0.05);significantly higher serum amyloid A(SAA)and C-reactive protein(CRP)in groups and the decline of which in observation group were lower than in control group(P<0.05);significantly lower platelet count and white blood cell count in groups were detected,which were more common to see in observation group(P<0.05);difference is no significant in liver function between groups before and after treatment(P>0.05).significantly decreased serum creatinine level in groups were detected and decreased degree in observation group was even lower(P<0.05);the quality of life and in groups were significantly improved and which in observation group were better(P<0.05);compared with control group,adverse reaction in observation group were lower(P<0.05).Conclusion FOLFIRI chemotherapy has a good therapeutic effect for patients with colorectal cancer;when combined with Buzhong Yiqi Decoction,it can further improve immunity and inflammatory reaction,improve quality of their life,reduce adverse reaction,which is a safe and effective and feasible for treatment.
作者
李培培
曹旸
王海存
兑伟华
Li Peipei;Cao Yang;Wang Haicun;Dui Weihua(Department of Digestion & Integrated Medicine Oncology, the Third People's Hospital of Zhengzhou, Zhengzhou 450000, China)
出处
《临床荟萃》
CAS
2021年第8期730-734,共5页
Clinical Focus
