摘要
目的探讨亚胺培南西司他丁钠联合血必净对重症肺炎患者T淋巴细胞亚群和血清炎性因子的影响。方法选择2017年2月至2019年7月我院诊治的62例重症肺炎患者,将其按信封抽签法分为对照组(n=31)和观察组(n=31)。对照组给予亚胺培南西司他丁钠治疗,观察组给予亚胺培南西司他丁钠联合血必净治疗,疗程均为2 w。对比两组治疗2周后的疗效,对比两组治疗前、治疗2周后的T淋巴细胞亚群和血清炎性因子,记录两组不良反应发生率。结果观察组的临床总有效率较对照组高(P<0.05)。治疗2周后,观察组CD8^(+)低于对照组,CD4^(+)/CD8^(+)、CD4^(+)、CD3^(+)高于对照组(P<0.05)。治疗2周后,观察组血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)水平低于对照组(P<0.05)。两组不良反应发生率比较无统计学差异(P>0.05)。结论亚胺培南西司他丁钠联合血必净治疗重症肺炎患者,可减轻机体炎症反应,提高机体免疫力,且安全有效。
Objective To investigate the effect of imipenem cilastatin sodium combined with Xuebijing on T lymphocyte subsets and serum inflammatory factors in patients with severe pneumonia.Methods 62 patients with severe pneumonia in our hospital from February 2017 to July 2019 were selected and divided into the control group(n=31)and the observation group(n=31)according to envelope lottery method.Patients in the control group were treated with imipenem cilastatin sodium,while those in the observation group were given imipenem cilastatin sodium combined with Xuebijing.The treatment course was two weeks in both groups.The curative effect of the two groups was compared.T lymphocyte subsets and serum inflammatory factors of the two groups before and after treatment were compared,and the incidence of adverse reactions in the two groups was recorded.Results The clinical total effective rate of the observation group was higher than that of the control group(P<0.05).After two weeks’treatment,CD8^(+)in the observation group was lower than that in the control group,and the CD4^(+)/CD8^(+),CD4^(+),CD3^(+)in the observation group were higher than those in the control group(P<0.05).After two weeks of treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the observation group were lower than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of severe pneumonia,imipenem cilastatin sodium combined with Xuebijing can reduce the inflammatory reaction and improve the immunity,which is safe and effective.
作者
尉飞
王湘雨
Wei Fei;Wang Xiangyu(Emergency Trauma Center,Henan Hospital of Traditional Chinese Medicine;The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000 China)
出处
《锦州医科大学学报》
2021年第4期31-34,共4页
Journal of Jinzhou Medical University
基金
河南省中医药科学研究专项课题,项目编号:2019JDZX065。
