摘要
为了将超声颗粒操纵技术应用于血管中纳米药物颗粒聚集,笔者针对液体流速因素的影响和纳米颗粒由于纳米效应存在的自发团聚现象,基于压电方程、声‑结构边界耦合方程、动量方程,利用COMSOL有限元软件建立了流速扰动聚焦超声下颗粒聚集的理论计算模型。通过仿真计算和实验结果对比分析,得到了聚焦超声聚集纳米颗粒的原因、纳米颗粒团簇介入解释理论以及流速干扰情况下局部流速变化的影响规律,证明了封闭管道中液体里的纳米颗粒可以通过聚焦超声的方式聚集,且该超声在流速小于1.92 mm/s的情况下仍对纳米颗粒团簇具有一定束缚能力,为未来靶向药物治疗提供一个新的方法和途径。
In order to apply ultrasonic particle manipulation technology to the aggregation of nano-drug particles in blood vessels,and aiming at the influence of flow rate and the spontaneous agglomeration of nanoparticles due to the nano effect,the theoretical calculation model of nanoparticle aggregation by focused ultrasound under flow rate disturbance is established using the COMSOL finite element software,based on the piezoelectric equation,the acoustic-structure boundary coupling equation,and the momentum equation.Through the comparison and analysis of simulation calculations and experimental results,the reasons for the aggregation of nanoparticles by focused ultrasound are obtained.The explanation theory of nanoparticle cluster intervention and the influence law of local flow rate changes under the interference of flow are also analyzed.It is proved that the nanoparticles liquid in the closed pipeline can be aggregated by focused ultrasound,which shows a certain binding ability to the nanoparticle clusters while the flow rate is less than 1.92 mm/s,providing a new method and approach for future targeted drug therapy.
作者
冒林丽
彭瀚旻
卢鹏辉
毛婷
MAO Linli;PENG Hanmin;LU Penghui;MAO Ting(State Key Laboratory of Mechanics and Control of Mechanical Structures,Nanjing University of Aeronautics and Astronautics Nanjing,210016,China)
出处
《振动．测试与诊断》
EI
CSCD
北大核心
2021年第4期784-791,836,共9页
Journal of Vibration,Measurement & Diagnosis
基金
国家自然科学基金资助项目(51875280)
江苏省优秀青年科学基金资助项目(BK201867)
江苏高校优势学科建设工程资助项目(PAPD)。
关键词
聚焦超声
纳米颗粒
靶向治疗
超声操纵
流体
有限元仿真
focused ultrasound
nano-particles
targeted therapy
ultrasonic manipulation
fluid
finite element simulation
