摘要
本研究探讨了善清金花茶对高脂血症模型小鼠体质量、血脂水平及肝功能的影响,为善清金花茶的开发和应用提供了科学依据。选取C57BL/6雄性小鼠40只,随机分为5组:空白对照组、模型组、阳性对照组、善清金花茶低、高剂量组。空白对照喂食普通饲料,其余各组采用高脂饲料喂养法制备高脂血症模型。经口灌胃给药8周后,测定各组小鼠的体质量、肝重、血清血脂水平、肝脏中超氧化物歧化酶(SOD)及丙二醛(MDA)的含量。结果显示,与模型组相比,经善清金花茶低剂量组给药后小鼠的总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)分别降低了20%、16.08%、21.54%,高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)提高了27.60%,动脉粥样硬化指数(atherosclerosis index,AI)及肝脏指数显著降低,肝脏组织中的SOD活性提高了19.29%,MDA含量降低了16.27%。可见善清金花茶具有调节高脂血症小鼠的血脂水平及保护肝脏的作用。
To obtain a scientific basis for the development and application of Shan Qing Camellia nitidissima tea,its effects on the body weight,lipid profile,and liver functions of hyperlipidemic mice were investigated.In total,40 C57BL/6 male mice were randomly divided into the following five groups:a blank control group,model group,positive control group,low-dose Shan Qing Camellia nitidissima tea-treated group,and high-dose Shan Qing Camellia nitidissima tea-treated group.The blank control group was fed with ordinary feed,whereas the other groups were fed a high-fat feed.The body weight,liver weight,and serum lipid levels as well as the superoxide dismutase(SOD)activity and malondialdehyde(MDA)level in the liver of each mouse were measured after 8 weeks of oral administration of the tea.The results showed that the total cholesterol(TC),triglyceride(TG),and low-density lipoprotein cholesterol(LDL-C)levels in the mice treated with the tea were 20%,16.08%, and 21.54% lower, respectively, than the levels in the model group of mice. Additionally, the high-density lipoprotein cholesterol (HDL-C) content had increased by 27.60%, whereas the atherosclerosis index (AI) and liver index had decreased significantly in the tea-treated mice. Moreover, the SOD activity had increased by 19.29%, whereas the MDA content in the liver had decreased by 16.27%. Obviously, Shan Qing Camellia nitidissima tea can regulate the lipid levels of hyperlipidemic mice and protect their liver.
作者
秦健峰
苏梓霞
郝二伟
蓝滴
陈锋
孙燕莲
韦玮
杜正彩
侯小涛
邓家刚
QIN Jian-feng;SU Zi-xia;HAO Er-wei;LAN Di;CHEN Feng;SUN Yan-lian;WEI Wei;DU Zheng-cai;HOU Xiao-tao;DENG Jia-gang(Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica,Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues,Guangxi Scientific Research Center of Traditional Chinese Medicine,Guangxi University of Chinese Medicine,Nanning 530200,China;Faculty of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China)
出处
《现代食品科技》
CAS
北大核心
2021年第8期30-35,共6页
Modern Food Science and Technology
基金
广西创新驱动发展专项(桂科AA18118049)
广西科技基地与人才专项(桂科AD19110165)
广西中药药效研究重点实验室建设项目(19-050-39)
2019年大学生创新创业训练计划项目(201910600003)。
关键词
金花茶
高脂血症
降血脂
保肝
Camellia nitidissima tea
hyperlipidemia
hypolipidemic effect
liver protection
