摘要
支气管肺发育不良(BPD)是早产儿尤其是极低出生体质量儿常见的慢性肺部疾病,现今仍然是早产儿发病率和病死率的重要原因。胰岛素样生长因子-1(IGF-1)作为一种促生长调节因子,可通过多种机制促进BPD患儿的肺发育和成熟,逆转肺发育阻滞进程,还可刺激胶原蛋白合成和增加肺3型固有淋巴细胞形成,从而减轻BPD炎症和肺损伤程度,间接预防心室肥大的发生。血清IGF-1水平降低与BPD发生及严重程度有高度相关性,维持其适宜的目标水平对防治BPD具有良好效益。
Bronchopulmonary dysplasia(BPD)is a common chronic lung disease in premature infants,especially in those with a very low birth weight,and remains a significant cause of morbidity and mortality in premature infants.Insulin-like growth factor-1(IGF-1),a growth-promoting regulator,promotes lung development and maturation in children with BPD through a variety of mechanisms,reversing the process of pulmonary developmental arrest.It also stimulates the synthesis of collagen and increases the formation of type 3 lung innate lymphoid cells,thereby reducing the degree of inflammation and lung injury in BPD and indirectly preventing the development of ventricular hypertrophy.The decrease in IGF-1 level in serum is highly related to the occurrence and severity of BPD,and maintaining its appropriate target level is beneficial to the prevention and treatment of BPD.
作者
梁锦灿
李薇
Liang Jincan;Li Wei(Department of Neonatology,Dongguan Hospital Affiliated to Jinan University,Dongguan 523900,China)
出处
《国际医药卫生导报》
2021年第16期2430-2433,共4页
International Medicine and Health Guidance News
