摘要
目的:研究分析桑夏扶正汤剂联合免疫球蛋白治疗重症病毒性肺炎临床疗效及安全性。方法:选取本院2019年4月至2020年8月收治的98例重症病毒性肺炎患者作为研究对象,按照不同治疗方式将其分为研究组(桑夏扶正汤剂联合免疫球蛋白治疗)及对照组(免疫球蛋白治疗)各49例。比较两组治疗效果,咳嗽咳痰、发热、咽痛、呼吸困难等症状消退时间,肿瘤坏死因子-α(tumor necrosis factor,TNF-α)、白介素-6(interleukin 6,IL-6)等炎性因子的变化情况,治疗前后免疫功能变化情况[免疫球蛋白A(Immunoglobin A,IgA)、免疫球蛋白G(ImmunoglobinG,IgG)、免疫球蛋白M(Immunoglobin A,IgM)]以及药物不良反应发生率。结果:(1)研究组总有效率明显高于对照组(95.92%vs 81.63%),两组比较具有显著差异(P<0.05)。(2)研究组咳嗽咳痰、发热、咽痛、呼吸困难等症状消退时间均低于对照组,具有显著差异(P<0.05)。(3)治疗后,两组TNF-α和IL-6水平较治疗前下降,且研究组下降水平更为显著(P<0.05)。(4)治疗后两组IgA、IgG水平较治疗前升高,IgM水平较治疗前降低;且研究组在治疗后IgA和IgG水平高于对照组,IgM水平低于对照组(P<0.05)。研究组与对照组不良反应总发生率比较未见明显差异(8.16%vs 6.12%)(P>0.05)。结论:桑夏扶正汤联合免疫球蛋白治疗重症病毒性肺炎临床疗效更佳,且可有效改善患者的免疫功能,减少炎症反应,促进患者症状缓解,安全性高,具有较高的临床应用价值。
Objective:To study and analyze the clinical efficacy and safety of using Sangxia Fuzheng Decoction combined with immunoglobulin in the treatment of severe viral pneumonia.Methods:98 patients with severe viral pneumonia admitted to our hospital from April 2019 to August 2020 were selected as the research objects.According to different treatment methods,they were divided into a study group(Sangxia Fuzheng Decoction combined with immunoglobulin therapy)and a controlled group(immunoglobulin therapy)with 49 cases in each group.The treatment effect,the time to relieve symptoms such as cough and expectoration,fever,sore throat,dyspnea,the changes in tumor necrosis factor-α(TNF-α),interleukin-6(interleukin 6,IL-6)and other inflammatory factors,and the changes in immune function before and after treatment[Immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)]and the incidence of adverse drug reactions between the two groups were compared.Results:(1)The total effective rate of the study group was significantly higher than that of the controlled group(95.92%vs 81.63%),and there was a significant difference between the two groups(P<0.05).(2)The time to relieve symptoms such as cough and expectoration,fever,sore throat,and dyspnea in the study group was lower than that in the controlled group,there was a significant difference(P<0.05).(3)After treatment,the levels of TNF-αand IL-6 in the two groups decreased compared with those before treatment,and the decrease in the study group was more significant(P<0.05).(4)After treatment,the levels of IgA and IgG in the two groups increased compared with those before treatment,and the level of IgM decreased compared with those before treatment.And after treatment,the levels of IgA and IgG in the study group were higher than those in the controlled group,and the IgM level was lower than that in the controlled group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the study group and the controlled group(8.16%vs 6.12%)(P>0.05).Conclusion:Sangxia Fuzheng Decoction combined with immunoglobulin has better clinical efficacy of treating severe viral pneumonia,and can effectively improve the patient’s immune function,reduce inflammation,promote the relief of patients’symptoms,and have high safety and high clinical application value.
作者
曾婕羚
ZENG Jieling(ICU of Xiehe Red Cross Hospital of Wuhan City,Wuhan Hubei 430000,China)
出处
《四川中医》
2021年第8期70-73,共4页
Journal of Sichuan of Traditional Chinese Medicine
基金
湖北省自然科学基金项目(编号:WJ2019MB056)。
