摘要
目的评价干细胞移植治疗缺血性脑卒中的有效性。方法应用计算机检索PubMed、Cochrane Library、Embase、Ovid、中国知网、万方和维普数据库,收集其中自建库至2021年3月公开发表的关于干细胞移植治疗缺血性脑卒中的随机对照试验(RCT)文献,依据纳入、排除标准对文献进行筛选并提取其中干细胞移植组与常规治疗组患者的临床资料,应用Stata 15.1软件对2组患者的美国国立卫生研究院卒中量表(NIHSS)评分、功能独立性量表(FIM)评分、肢体运动功能评定量表(FMA)评分、Barthel指数(BI)、日常生活能力评定量表(ADL)评分、改良Rankin量表(mRS)评分的基线值与终值的差值的合并值进行Meta分析。结果共纳入18篇文献,包含1334例患者,其中干细胞移植组668例,常规治疗组666例。Meta分析显示,干细胞移植组患者的NIHSS评分[均数差(MD)=3.510,95%CI:2.540~4.480,P=0.000]、FIM评分(MD=11.380,95%CI:5.470~17.280,P=0.000)、FMA评分(MD=13.830,95%CI:12.590~15.070,P=0.000)、BI(MD=22.100,95%CI:19.430~24.770,P=0.000)、ADL评分(MD=9.290,95%CI:3.530~15.050,P=0.002)、mRS评分(P=0.004)的改善程度均明显优于常规治疗组,差异均有统计学意义(P<0.05)。结论常规治疗基础上进行干细胞移植对缺血性脑卒中患者的神经功能恢复、日常生活活动能力改善及肢体运动功能改善均有更好的效果。
Objective To evaluate the efficacy of stem cell transplantation in treatment of ischemic stroke.Methods Randomized controlled studies about stem cell transplantation in the treatment of ischemic stroke were searched from Pubmed,Cochrane Library,Embase,Ovid,China National Knowledge Infrastructure(CNKI),Wanfang and VIP database from database establishment to March 2021.The literature was screened according to the inclusion and exclusion criteria and the clinical data of the stem cell transplantation patients and conventional treatment patients were extracted.The differences of baseline value and final value of National Institutes of Health Stroke Scale(NIHSS)scores,Function Independent Measurement(FIM)scores,Fugl-Meyer Measurement(FMA)scores,Barthel index(BI),Activity of Daily Living(ADL)scale scores,modified Rankin scale(mRS)scores between the two groups were combined for Meta analysis.Results Eighteen articles were included in the study,including 1334 patients;668 patients were from the stem cell transplantation group and 666 patients were from the conventional treatment group.The results showed that NIHSS scores(difference in means[MD]=3.510,95%CI:2.540-4.480,P=0.000],FIM scores(MD=11.380,95%CI:5.470-17.280,P=0.000),FMA scores(MD=13.830,95%CI:12.590-15.070,P=0.000),BI(MD=22.100,95%CI:19.430-24.770,P=0.000),ADL scores(MD=9.290,95%CI:3.530-15.050,P=0.002),and mRS scores(P=0.004)in the stem cell transplantation group were significantly higher as compared with those in the conventional treatment group(P<0.05).Conclusion Stem cell transplantation on the basis of conventional treatment has good clinical efficacy in the recovery of neurological function,improvement of activity of daily living,and improvement of limb motor function in patients with ischemic stroke.
作者
丁佳
姚剑蓉
吴慧娴
叶丹
练学淦
Ding Jia;Yao Jianrong;Wu Huixian;Ye Dan;Lian Xuegan(Department of Neurology,Third Affiliated Hospital of Suzhou University(Changzhou First People's Hospital),Changzhou 213000,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2021年第8期812-820,共9页
Chinese Journal of Neuromedicine
基金
常州市卫健委重大科技项目(ZD201904)。
