摘要
嗜黏蛋白艾克曼菌Akkermansia muciniphila简称AKK菌,于2004年被发现。AKK菌是从人体肠道中被分离出来的一种椭圆形革兰阴性菌,被作为黏液降解菌,广泛存在于人体肠道中,能在肠道黏液层中增殖,并依靠宿主分泌的黏蛋白进行生存。越来越多的研究表明,AAK菌可发挥益生菌作用,在糖尿病、肝脏疾病、心血管疾病、炎症性肠病、神经退行性疾病等疾病中都发现其丰度降低。除此之外,AKK菌可以与中药相互作用治疗疾病,但背后作用机制尚未明确,需要继续进行深入研究。因此该文将综述AKK菌的主要功效及其与中药之间的联系,总结主要存在的问题,为AKK菌的进一步的研究和深入探讨药理作用机制奠定基础。
Akkermansia muciniphila, abbreviated as AKK and found in 2004, is an oval-shaped gram-negative bacterium isolated from a human feal. A. muciniphila is widely present in the intestinal tract of human. Its specialization in mucin degradation makes it a key organism at the mucosal interface between the lumen and host cells. More and more studies have shown that it can play the role of probiotics. Notably, declined levels of A. muciniphila have been observed in patients with diabetes, liver disease, cardiovascular disease, inflammatory bowel disease, neurodegenerative diseases, etc. In addition, A. muciniphila combined with traditional Chinese medicine, exhibited higher effect on regulating host functions, but the underlying mechanism was still unclear, requiring further in-depth research. Therefore, the aims of this review are to summarize the main effects of A. muciniphila on host health and its relationship with traditional Chinese medicine, summarize the main problems, and provide a reference for the further research of A. muciniphila and traditional Chinese medicine.
作者
马文玉
冯世秀
陈乃宏
MA Wen-yu;FENG Shi-xiu;CHEN Nai-hong(Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Key Laboratory of Southern Subtropical Plant Diversity,Fairy Lake Botanical Garden,Shenzhen&Chinese Academy of Sciences,Shenzhen 518004,China;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medical&Neuroscience Center,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2021年第11期2760-2765,共6页
China Journal of Chinese Materia Medica
基金
海南省财政科技计划项目(ZDYF2018228)
仙湖植物园重点基金项目(2019)。
关键词
嗜黏蛋白艾克曼菌
中药
益生作用
肠道菌群
Akkermansia muciniphila
traditional Chinese medicine
probiotics
intestinal flora
