摘要
从中医学视角来看,甲状腺多气多血,其生理功能有赖于血脉的重要作用。认为甲状腺血脉功能异常引起Graves病的发生,其主要病理因素为火、痰、瘀,而火、痰、瘀的产生与甲状腺血管新生密切相关。中医治疗Graves病的基本方法均与调血脉之法密切相关,药理研究亦表明,夏枯草、土贝母等常用于治疗Graves病的中药具有抑制血管新生的作用,因此抑制甲状腺血管新生可能是调血脉之法治疗Graves病的作用机制之一。
Thyroid is considered to be full of qi and blood in traditional Chinese medicine(TCM),and its physiological function is closely related to blood vessels.Abnormal function of thyroid blood vessels may lead to the occurrence of Graves′disease(GD).It is believed that the main pathological factors of Graves′disease are fire,phlegm and stasis,the formulation of GD is closely related to thyroid angiogenesis.The basic TCM treatment methods for GD are all related to the regulation of blood vessels.Pharmacological studies have also shown that commonly used Chinese herbs for GD,such as Xiakucao(Spica Prunellae)and Tubeimu(Rhizoma Bolbostematis)Fritillaria vulgaris,have the effect of inhibiting angiogenesis.Therefore,the inhibition of thyroid angiogenesis may be one of the mechanism of blood vessels regulating method for GD.
作者
马文欣
刘金民
汤阳
朱晓云
徐婧
刘喜明
MA Wenxin;LIU Jinmin;TANG Yang;ZHU Xiaoyun;XU Jing;LIU Ximing(Graduate School of Beijing University of Chinese Medicine,Beijing,100029;Guang'anmen Hospital,China Academy of Chinese Medical Sciences;Dongfang Hospital,Beijing University of Chinese Medicine;Beijing University of Chinese Medicine)
出处
《中医杂志》
CSCD
北大核心
2021年第14期1224-1227,共4页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81774293,82004337)
北京中医药大学2020年度基本科研业务费(2020-JYB-XJSJJ-002)。
关键词
GRAVES病
血管新生
调血脉
Graves′disease
angiogenesis
regulating blood vessels
