摘要
目的观察美索巴莫注射液对严重创伤及骨折围手术期镇痛的临床有效性与安全性。方法2018年9月~2019年7月诊治的严重创伤及骨折病人200例。依据术后接受镇痛治疗方式不同,将其分为两组,对照组100例,采用非甾体抗炎镇痛药治疗;实验组100例,采用非甾体抗炎镇痛药联合美索巴莫注射液治疗。入院后均给予非甾体抗炎镇痛药基本治疗,实验组在此基础上加用美索巴莫注射液(1 g溶于生理盐水100 ml)静脉滴注,每天2次,3天为1个疗程。比较两组术后24小时血压、呼吸、心率、体温等生命体征、生活质量评分和急性疼痛加重次数。连续记录和比较两组病人术后72小时内疼痛评分并作有效性和安全性评价。结果两组间平均血压和呼吸频率比较无明显差异,实验组心率[(73.4±2.4)次/分],体温[(37.0±0.1)℃],急性疼痛加重次数(1.8±0.6),72小时内疼痛评分低于对照组,差异有统计学意义(P<0.05)。实验组生活质量评分(70.6±11.3)和镇痛总体有效率(89%)优于对照组,差异有统计学意义(P<0.05)。结论对于严重创伤及骨折围手术期的病人在常规自控镇痛基础上加用美索巴莫注射液可有效且安全地提高镇痛效果,有利于早期功能锻炼,提高关节活动度。
Objective To observe and investigate the clinical efficacy and safety of mezobamo injection in the perioperative analgesia of severe trauma and fracture.Methods A total of 200 patients with severe trauma and fracture diagnosed and treated in the hospital from September 2018 to July 2019 were selected in a randomized and controlled study.100 cases in the experimental group and 100 cases in the control group.All patients were treated with non-steroidal anti-inflammatory and analgesic drugs after admission.On this basis,the patients in the experimental group were given mezobamo injection(1 g dissolved in 100 ml of normal saline)intravenously,twice a day and three days as a course of treatment.VITAL SIGNS,such as blood pressure,respiration,heart rate and body temperature,quality of life scores and exacerbations of acute pain at 24 h after surgery were compared between the two groups.The pain scores within 72 hours after surgery were recorded and compared continuously between the two groups,and the efficacy and safety were evaluated.Results There were no significant differences in average blood pressure and respiration between the two groups.Heart rate(73.4±2.4),body temperature(37.0±0.1)℃,acute pain aggravation times(1.8±0.6)in the experimental group were significantly lower than those in the control group within 72 hours(P<0.05).Experimental life quality score(70.6-11.3)and overall efficient analgesic(89%)were significantly better than that of control group(P<0.05).Conclusion For perioperative patients with severe trauma and fractures on the basis of conventional self-control analgesia with methocarbamol injection can improve effective and safe analgesic effect,in the interest of early functional exercise,improve the joint activity.
作者
何泽希
陈东
詹惺捷
刘国辉
HE Zexi;CHEN Dong;ZHAN Xingjie(Department of Orthopaedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)
出处
《临床外科杂志》
2021年第6期577-579,共3页
Journal of Clinical Surgery
关键词
创伤
骨折
止痛
美索巴莫注射液
trauma
fracture
analgesia
mezobamo injection
