摘要
胃癌(gastriccancer)是普外科常见的胃肠道肿瘤,目前主要治疗方案为手术根治切除+放化疗,但国内胃癌5年生存率依然有待提高。二甲双胍(metformin)是一种常见的降糖药,近年来发现其对肺癌(lung cancer)、乳腺癌(breast cancer)、前列腺癌(prostate cancer)、子宫内膜癌(endometrial cancer)、结直肠癌(colorectal cancer)等恶性肿瘤有降低发生风险及抑制作用。然而,关于二甲双胍对胃癌的作用原理尚未明确,本文通过国内外已有文献,综述二甲双胍对胃癌抗肿瘤作用的研究进展,以期为临床诊治提供参考。
Gastric cancer is a common gastrointestinal tumor in general surgery.The main treatment strategies are radical resection and chemo-radiotherapy,but the five-year survival rate still needs to be improved in China.Metformin,a common hypoglycemic drug,has been found to reduce the risk and inhibit the occurrence of several cancers includes lung,breast,prostate,endometrial and colorectal cancers.However,the mechanism of metformin on gastric cancer is remaining unclear.This review showed the research progress on the anti-tumor mechanism of metformin on gastric cancer through existing literature at home and abroad to provide reference for clinical diagnosis and treatment.
作者
钱佳晟
陈志红
QIAN Jiasheng;CHEN Zhihong(Department of General Surgery,People's Hospital Affiliated to Jiangsu University,Zhenjiang 212002,Jiangsu Province,China)
出处
《世界临床药物》
2021年第7期595-598,共4页
World Clinical Drug
关键词
二甲双胍
胃癌
抗肿瘤机制
metformin
gastric cancer
anti-tumor effect
