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XDRAB颅内感染多途径应用替加环素治疗的病例分析及文献回顾 被引量:7

Analysisand literature review of intracranial infection caused by XDRAB treated by tigecycline via multiple channels
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摘要 鲍曼不动杆菌是常见机会性院内感染致病菌,近年来其耐药性不断增强,已由多重耐药发展至对临床常用抗菌药物普遍耐药,其导致的颅内感染预后极差,治疗较为困难,虽然替加环素对鲍曼不动杆菌活性较强,但因其脑脊液浓度低,FDA未批准其用于治疗颅内感染。本文报道临床药师参与1例泛耐药鲍曼不动杆菌致颅内感染的治疗,查阅文献协助医师制定替加环素多途径用药方案,使感染得到有效控制,并对相关文献做了文献回顾,目前研究结果证实其治疗颅内感染是有效的,经颅内给药治疗颅内耐药菌感染的研究多为个案报道,其在颅内感染中的应用还需进一步的研究证实。
作者 李长秀 张晗 王擂 党和勤 LI Chang-xiu;ZHANG Han;WANG Lei;DANG He-qin(Second Affiliated Hospital,Shandong First Medical University,Shandong Tai'an 271000,China)
出处 《中国医院药学杂志》 北大核心 2021年第16期1683-1687,共5页 Chinese Journal of Hospital Pharmacy
基金 吴阶平医学基金会临床科研专项资助基金(编号:320.6750.2020-17-1)。
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