摘要
类器官是体外构建的一类由多种类型细胞组成的,与体内器官或组织高度相似的三维培养物,它能够模拟细胞所属器官的某些结构和生理功能。心血管疾病患病率及死亡率一直处于上升阶段,相关基础研究主要基于细胞和动物模型。心脏类器官是对传统心血管疾病模型的有效补充,在体外更真实和准确地反映人体心脏的生物学特性和功能,使其在疾病机制研究、药物开发、精准医疗和再生医学等领域具有广泛应用前景和独特优势。该文主要介绍了心脏类器官作为新一代疾病模型在心肌梗死、心力衰竭、遗传性心脏病和心律失常等方面的应用,并探讨了类器官技术未来的发展方向和面临的挑战。
Organoid is an in vitro formed three-dimensional structure,which contains different cell types and can simulate some of the structures and functions of its representative organ.The prevalence and mortality of cardiovascular disease have been on the rise,and the related research experiments are mainly based on cell and animal models.Cardiac organoid is an effective supplement to the traditional cardiovascular disease model.To a certain extent,cardiac organoid reflects the key biological characteristics of human heart more truly and accurately.Therefore,cardiac organoid has broad application prospects and unique advantages in the fields of disease mechanism research,drug evaluation,precision medicine and regenerative medicine.Here,the applications of cardiac organoid are mainly introduced as new generation of disease model in myocardial infarction,heart failure,genetic heart diseases and arrhythmia.In addition,the prospects and limitations of cardiac organoids are proposed.
作者
赵丹丹
雷伟
胡士军
ZHAO Dandan;LEI Wei;HU Shijun(Institute for Cardiovascular Science,Medical College,Soochow University,Suzhou 215000,China;State Key Laboratory of Radiation Medicine and Protection,Medical College,Soochow University,Suzhou 215000,China)
出处
《中国细胞生物学学报》
CSCD
2021年第7期1333-1340,共8页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:82000263、91949111、81770257)
中国博士后科学基金(批准号:2018M642316)资助的课题。
关键词
心脏类器官
多能干细胞
心血管疾病
cardiac organoid
pluripotent stem cells
cardiovascular disease
