摘要
目的探究布-加综合征(BCS)发病机制与尿液中高浓度碘的相关性。方法选择2018年期间收治的115例BCS患者(实验组)和健康体检者120例(对照组),采用化学法分别进行尿碘水平检测。采用独立样本t检验进行两组间尿碘水平比较,采用单因素方差分析对最新BCS亚型分型肝静脉(HV)型、下腔静脉(IVC)型和混合型,以及病理解剖分型隔膜型、血栓型和管腔狭窄型患者尿碘水平进行比较。结果实验组、对照组尿碘水平分别为平均(456.9±257.4)μg/L、(118.3±232.1)μg/L,实验组显著较高(P=0.012)。实验组尿碘水平在性别、年龄间差异均无统计学意义(P>0.05)。IVC型、HV型、混合型患者尿碘水平分别为平均(771.4±367.4)μg/L、(294.3±312.1)μg/L、(490.1±287.7)μg/L,IVC型均高于HV型、混合型(P<0.05);隔膜型、血栓型、管腔狭窄型患者尿碘水平分别为平均(794.3±307.3)μg/L、(597.5±281.3)μg/L、(631.5±377.9)μg/L,隔膜型均高于血栓型、管腔狭窄型(P<0.05)。结论尿碘水平增高在BCS发病因素研究中有一定的临床意义。高碘与IVC型及隔膜型BCS有更确切的相关性。
Objective To investigate the correlation between high concentration of iodine in urine and Budd-Chiari syndrome(BCS). Methods A total of 115 BCS patients who were admitted to the Affiliated Hospital of Xuzhou Medical University of China in 2018(study group) and 120 healthy subjects(control group)were enrolled in this study. Using chemical method the urine iodine concentration was tested. The urine iodine concentration was compared by using independent sample t test. Univariate ANOVA analysis was used to compare the urine iodine concentrations between each other among the hepatic vein(HV) type, inferior vena cava(IVC) type and mixed type, as well as between each other among the pathological anatomy types, including membranous type, thrombus type and lumen stenosis type;the above subtyping criterion was based on the latest classification of BCS subtypes. Results The urine iodine concentration in the study group was(456.9±257.4) μg/L, which was remarkable higher than(118.3±232.1) μg/L in the control group(P=0.012). In the study group, no statistically significant difference in urine iodine concentration existed between different sex and patient’s age(P>0.05). The mean urine iodine concentration in IVC type was(771.4±367.4) μg/L, which was higher than(294.3±312.1) μg/L in HV type as well as higher than(490.1±287.7) μg/L in mixed type(P<0.05). The mean urine iodine concentration in pathological membranous type was(794.3±307.3) μg/L,which was higher than(597.5±281.3) μg/L in thrombus type as well as higher than(631.5±377.9) μg/L in lumen stenosis type(P<0.05). Conclusion The elevated urine iodine concentration has certain clinical significance in studying the aetiology of BCS. Higher urine iodine concentration carries more definitive correlation with IVC type BCS and pathological membranous type BCS.(J Intervent Radiol, 2021, 30: 765-768)
作者
李琳
顾玉明
祖茂衡
徐浩
LI Lin;GU Yuming;ZU Maoheng;XU Hao(Department of Interventional Radiology,Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu Province 221006,China)
出处
《介入放射学杂志》
CSCD
北大核心
2021年第8期765-768,共4页
Journal of Interventional Radiology
关键词
布-加综合征
碘
下腔静脉
隔膜型
Budd-Chiari syndrome
iodine
inferior vena cava
membranous type
