摘要
心肌缺血/再灌注损伤(myocardial ischemia/reperfusion injury,MI/RI)是缺血性心脏病、心脏手术中常见的病理过程,缺血/再灌注过程中线粒体损伤和功能障碍是MI/RI的重要原因。目前发现将功能完整的线粒体移植到病变组织后,通过其内化、与内源性线粒体融合等途径来替代或修复受损的线粒体,从而增强组织能量代谢,挽救心肌细胞,恢复组织功能。文章介绍了外源性线粒体的分离技术、输注方法、线粒体内化和融合的相关机制,就线粒体移植对MI/RI的保护作用及其对心脏移植作用的最新研究进展进行综述。线粒体移植为保护MI/RI开辟了一条新的治疗途径。
Myocardial ischemia/reperfusion injury(MI/RI)is a common pathological process in ischemic heart disease and car‑diac surgery.Mitochondrial injury and dysfunction are the main causes of MI/RI during ischemia/reperfusion.So far,it has found that after transplantation of intact mitochondria into the diseased tissue,the damaged mitochondria can be replaced or repaired by internal‑ization and fusion with endogenous mitochondria,so as to enhance tissue energy metabolism,save cardiomyocytes and restore tissue function.This review introduces the isolation of exogenous mitochondria,infusion methods,and the mechanisms of mitochondrial inter‑nalization and fusion,while summarizing the latest research progress on the protection of MI/RI by mitochondrial transplantation and the effect of mitochondrial transplantation on heart transplantation.Mitochondrial transplantation provides a new therapeutic approach to protect against MI/RI.
作者
玉素普·努尔麦麦提
古丽尼格尔·艾尔肯
王江
Yusupu Nuermaimaiti;Gulinigeer Aierken;Wang Jiang(Department of Anesthesiology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
出处
《国际麻醉学与复苏杂志》
CAS
2021年第8期892-896,共5页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金(81960053)。
关键词
线粒体移植
心肌保护
缺血/再灌注损伤
Mitochondrial transplantation
Myocardial protection
Ischemia/reperfusion injury
