摘要
目的分析小剂量雄激素联合精索静脉高位结扎术治疗少弱精子症并精索静脉曲张的治疗效果。方法选取2019年12月—2021年1月间该院泌尿外科收治的100例少弱精子症并精索静脉曲张患者,依据治疗方法分为观察组(IG)和对照组(CG),每组50例。其中,CG组采用精索静脉高位结扎术;IG组在CG组治疗方法的基础上,口服小剂量安特尔。观察各组的精液常规指标,果糖、碱性磷酸酶,以及生殖激素5项。结果IG组的精液密度(54.82±1.98)×10^(6)/mL、前向运动精子比例(41.91±1.17)%、精子活动率(51.71±1.24)%均优于CG组的(51.23±1.61)×10^(6)/mL、(38.44±1.26)%、(47.97±1.07)%,差异有统计学意义(t=9.947、14.270、16.147,P<0.05);IG组的酸性磷酸酶(273.13±4.23)U/L、果糖(17.14±4.12)μmol/L均高于CG组的(265.31±4.18)U/L、(25.31±4.18)μmol/L,而IG组的液化时间(23.27±1.19)min低于CG组的(24.81±1.64)min,差异有统计学意义(t=9.298、9.483、5.374,P<0.05);IG组的催乳素(PRL)(8.83±0.34)mU/L、睾酮(T)(19.96±0.98)nmol/L水平均优于CG组的(8.53±1.10)mU/L、(19.37±1.06)nmol/L,而卵泡刺激素(FSH)(6.02±1.02)IU/L、黄体生成素(LH)(5.38±0.03)IU/L和雌二醇(E_(2))(23.27±1.19)nmol/L水平低于CG组(6.81±0.99)IU/L、(5.42±0.01)IU/L、(24.81±1.64)nmol/L,差异有统计学意义(t=5.986、2.890、3.930、8.944、5.374,P<0.05)。结论小剂量雄激素联合精索静脉高位结扎术可以治疗少弱精子症合并精索静脉曲张,且治疗效果优于单一的传统手术方式,具有临床推广意义。
Objective To analyze the therapeutic effect of low-dose androgen combined with high spermatic vein ligation in the treatment of oligoasthenospermia and varicocele.Methods A total of 100 patients with oligoasthenospermia and varicocele were selected from December 2019 to January 2021.The patients were divided into observation group(IG)and control group(CG)according to the treatment method.Each group was divided into observation group(IG)and control group(CG)with 50 cases.Among them,the CG group used high ligation of the spermatic vein;the IG group received a small dose of Antel based on the treatment of the CG group.Observed the semen routine indexes of each group,5 items of fructose,alkaline phosphatase,and reproductive hormones.Results The semen density of the IG group(54.82±1.98)×10^(6)/mL,the proportion of forward motile sperm(41.91±1.17)%,and the sperm motility rate(51.71±1.24)%were better than those of the CG group(51.23±1.61)×10^(6)/mL,(38.44±1.26)%,(47.97±1.07)%,the difference was statistically significant(t=9.947,14.270,16.147,P<0.05);acid phosphatase(273.13±4.23)U/L,fructose content(17.14±4.12)mol/L was higher than(265.31±4.18)U/L and(25.31±4.18 mol/L)in the CG group,while the liquefaction time(23.27±1.19)min in the IG group was lower than that in the CG group(24.81±1.64)min,the difference was statistically significant(t=9.298,9.483,5.374,P<0.01);prolactin(PRL)(8.83±0.34)mU/L and testosterone(T)(19.96±0.98)nmol/L levels of the IG group were better than those of the CG group(8.53±1.10)mU/L,(19.37±1.06)nmol/L,while follicle stimulating hormone(FSH)(6.02±1.02)IU/L,luteinizing hormone(LH)(5.38±0.03)IU/L and estradiol(E_(2))(23.27±1.19)nmol/L,lower than CG group(6.81±0.99)IU/L,(5.42±0.01)IU/L,(24.81±1.64)nmol/L,the difference was statistically significant(t=5.986,2.890,3.930,8.944,5.374,P<0.05).Conclusion Low-dose androgen combined with high spermatic ligation can treat oligoasthenospermia complicated with varicocele,and the therapeutic effect is better than that of a single traditional surgical method,which has clinical significance.
作者
刘继普
钟煜韡
郑永宏
张碧如
林惠芳
LIU Jipu;ZHONG Yuwei;ZHENG Yonghong;ZHANG Biru;LIN Huifang(Department of Urology,Huizhou Sixth People's Hospital,Huizhou,Guangdong Province,516200 China)
出处
《世界复合医学》
2021年第6期27-31,共5页
World Journal of Complex Medicine
基金
广东省医学科学技术研究基金(A2017470)。
