摘要
为探索浓缩液的黏度与临方浓缩水丸制剂成型的相关性,该研究采用旋转流变仪,建立了临方制剂浓缩液黏度的表征方法,选取7个模型处方进行不同浓缩阶段浓缩液黏度的测定,结果表明浓缩液在"挂旗中期"存在"黏度突跃"现象,提示在临方浓缩水丸制备过程中可能存在可制备理想丸剂的适宜黏度范围。以22个模型处方共81个样品的研究进一步表明:约82%处方的浓缩液黏度适宜范围为5~15 Pa·s(25℃),约18%的处方黏度适宜黏度较大,可能与"为辅"的粉碎部分中矿物药和甲壳类的占比和"为药"的煎煮部分中糖性料和纤维料的占比较高有关。该研究明确了中药临方浓缩水丸的浓缩液的适宜黏度范围,实现了"零辅料"临方浓缩水丸的制备技术,为中药临方浓缩水丸制备的在线控制奠定了基础。
To explore the correlation between concentrate viscosity and molding quality of personalized traditional Chinese medicine(TCM) condensed water pill, this study established a concentrate viscosity characterization method with rotational rheometry. Seven model prescriptions were respectively concentrated to different degrees and the viscosity of each concentrate was determined. The pre-sence of ′viscosity jump′ in the middle stage of ′flag hanging′ of all the model prescriptions implied that there might be an ideal viscosity range in the preparation of condensed water pill. The further study of 22 model prescriptions demonstrated that the optimum viscosity range of concentrate was 5-15 Pa·s(25 ℃) for approximately 82% of the prescriptions. About 18% of the prescriptions had a wide range, which might be caused by the high proportions of mineral and crustacean drugs in the crushing part and sugar and fibrous drugs in the decocting part. This study clarified the optimum viscosity range for concentrates of personalized TCM condensed water pills and achieved a preparation technology without any excipient, laying a foundation for the on-line control of the preparation.
作者
张雪
胡志强
林晓
张磊
王优杰
沈岚
洪燕龙
ZHANG Xue;HU Zhi-qiang;LIN Xiao;ZHANG Lei;WANG You-jie;SHEN Lan;HONG Yan-long(Shanghai Traditional Chinese Medicine Health Service Collaborative Innovation Center,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine,Ministry of Education,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2021年第15期3772-3779,共8页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81973490)
上海市自然科学基金项目(18ZR1436600,19ZR1457700,18ZR1439800)
上海市“科技创新行动计划”技术标准项目(20DZ2200900)
上海市卫计委中医药事业发展三年行动计划项目[ZY(2018-2020)-CCCX-2001-03]
2021年度上海市协同创新中心建设项目(2021科技01-01-30)。
关键词
中药临方制剂
浓缩水丸
药辅合一
挂旗
黏度
personalized traditional Chinese medicine(TCM)preparations
condensed water pill
unification of medicine and excipients
flag hanging
viscosity
