摘要
目的通过回顾性调查,综合评价新疆某三甲医院抗肿瘤药物超说明书用药情况,分析临床药学的干预作用,为制订抗肿瘤药物超说明书用药管理方案提供参考依据。方法建立临床药学点评及反馈工作流程,随机抽查2018年1月-2019年12月抗肿瘤药物医嘱,依照药品说明书内容逐条审核,比较干预前(2018年1-12月)及干预后(2019年1-12月)超说明书用药情况。结果干预后抗肿瘤药物超说明书用药发生率下降,按照病例数、用药医嘱条数、药品品种数计算,干预前发生率分别为42.30%、29.12%、67.65%,干预后发生率分别为30.00%、25.95%、51.16%。干预后超适应证用药、超用药人群用药比例明显降低(分别降至48.63%、3.83%)。对超说明书用药的临床医师按不同职称分类,干预后副主任医师、主治医师和医师的超说明书用药发生率有所下降,但差异无统计学意义(P>0.05)。结论该院抗肿瘤药物超说明书现象与国内外研究结果相似,化疗药物为该院主要的超说明书用药抗肿瘤药物,通过临床药学干预,可改善超说明书用药发生比例及临床医师用药行为,协助临床做好抗肿瘤药物超说明书用药的工作,还可进一步加深和细化。
Objective Through retrospective investigation,the situation of off-label drug use of anti-tumor drugs in a third-class a hospital in Xinjiang was comprehensively evaluated,and the intervention effect of clinical pharmacy was analyzed,so as to provide reference for the formulation of off-label drug use management plan of anti-tumor drugs.Methods The working process of clinical pharmacy review and feedback were established,the medical orders of antitumor drugs from January2018 to December 2019 were randomly checked,the off-label drug use was compared before the intervention(January to December 2018)and after the intervention(January to December 2019)according to the contents of drug instructions.Results The incidence of off-label use of antitumor drugs decreased after intervention,and the incidence before intervention were 42.30%,29.12%and 67.65%respectively,according to the number of cases,the number of medical orders and the number of drug varieties.The post-intervention incidence rates were 30.00%,25.95%and 51.16%respectively.After intervention,the proportion of drug use beyond indications and the proportion of drug use in people with excessive indications decreased significantly(reduced to 48.63%and 3.83%respectively).The incidence of off-label drug use of associate chief physicians,attending physicians and physicians decreased after intervention,but the difference was not statistically significant(P>0.05).Conclusion Its antitumor drugs over manual phenomenon is similar to the research results at home and abroad,chemotherapy drugs as its major exceed manual medicine anti-tumor drugs,through the intervention of clinical pharmacy,can improve the super instruction preparation proportion and the clinician behavior,to assist clinical antitumor drug drug than manual work,also can further deepen and refine.
作者
李亚昙
蔡静
贾蔓箐
贾巍
刘军
LI Yatan;CAI Jing;JIA Manqing(Department of Pharmacy,Second Affiliated Hospital of Xinjiang Medical University,Xinjiang Uygur Autonomous Region,Urumqi 830028,China;不详)
出处
《临床合理用药杂志》
2021年第25期1-4,共4页
Chinese Journal of Clinical Rational Drug Use
基金
新疆维吾尔自治区自然科学基金项目(No:2018D01C224)。
关键词
抗肿瘤药物
超药品说明书
用药干预
Antitumor drugs
Exceeding the drug label
Drug intervention
