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环磷酰胺冲击疗法联合激素治疗系统性红斑狼疮性肾炎患者的效果 被引量:1

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摘要 目的:观察环磷酰胺冲击疗法联合激素治疗系统性红斑狼疮性肾炎患者的效果。方法:选取66例系统性红斑狼疮性肾炎患者作为研究对象,依据随机数字表法分为对照组与研究组各33例。对照组采用激素治疗,研究组在对照组基础上联合环磷酰胺冲击疗法治疗,比较两组治疗前后免疫指标[免疫球蛋白(Ig)A、IgG、IgM]水平、炎性指标[肿瘤坏死因子-α(TNF-α)、α干扰素(INF-α)、白细胞介素-6(IL-6)]水平、治疗总有效率、不良反应发生率和肾功能指标(尿蛋白定量、尿素氮、血肌酐)水平。结果:治疗后,研究组IgA、IgG、IgM、TNF-α、INF-α和IL-6水平均低于对照组,差异有统计学意义(P<0.05);研究组治疗总有效率为96.97%(32/33),高于对照组的72.73%(24/33),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);治疗后,观察组尿蛋白定量、尿素氮和血肌酐水平均低于对照组,差异有统计学意义(P<0.05)。结论:环磷酰胺冲击疗法联合激素治疗系统性红斑狼疮性肾炎患者可提高治疗总有效率,降低免疫指标、炎性指标和肾功能指标水平,效果优于单纯激素治疗。
作者 闫秋宇
出处 《中国民康医学》 2021年第15期48-50,共3页 Medical Journal of Chinese People’s Health
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