摘要
侵袭性念珠菌病在危重症患者中发病率较高,由于其临床症状不典型,诊断与治疗常被延误,导致其较高的病死率。同时,引起侵袭性感染的念珠菌菌种分布也逐年变化,非白念珠菌所致感染已超过白念珠菌,致病菌种及其耐药分布的变迁造成临床抗真菌药物选择的困难。本文对我国侵袭性念珠菌病的流行现状及病原学特点进行总结,以帮助对其进行早期诊断、合理治疗。
Invasive candidiasis presents with high incidence in critically ill patients.Due to its atypical manifestation,the diagnosis and treatment is often delayed,which contributes to its high mortality.In addition,the distribution of Candida species is changing by years,and Candida non-albicans has become more prevalent than Candida albicans.The consisting changes in the distribution of Candida species and drug resistance lead to difficulties in the antifungal therapy.The current epidemiology and pathogenic distribution of invasive candidiasis in China are summarized in this paper,aiming to assist early diagnosis and appropriate treatment.
作者
杨之辉
余进
李若瑜
Yang Zhihui;Yu Jin;Li Ruoyu(Department of Dermatology and Venerology,Peking University First Hospital,Research Center for Medical Mycology,Peking University,National Clinical Research Center for Skin and Immune Diseases,Beijing Key Laboratory of Molecular Diagnosis of Dermatoses,NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics,Beijing 100034,China)
出处
《国际流行病学传染病学杂志》
CAS
2021年第4期266-271,共6页
International Journal of Epidemiology and Infectious Disease
基金
国家重点研发计划(2020YFC2005401)。
关键词
念珠菌病
侵袭性
流行病学
发病率
病原学
人群监测
Candidiasis,invasive
Epidemiology
Incidence
Pathology
Population surveillance
