摘要
目的比较不同剂量的左旋甲状腺素钠片对妊娠合并甲减进行治疗的临床效果。方法选择2017年4月至2019年6月来我院进行治疗的妊娠合并甲减患者42例作为本文观察组,另外选择同期来我院进行治疗的42例妊娠合并甲减患者作为对照组,两组患者均选择采用左旋甲状腺素纳片进行治疗,观察组患者根据患者的血清甲状腺激素水平确定药物剂量,而对照组患者应用的剂量为125μg,对两组患者治疗之后的效果进行评价和比较。结果观察组自然分娩率为85.71%(36/42),对照组为47.62%(20/42),P<0.05;观察组妊娠合并症的发生率为28.57%(12/42),对照组为54.76%(23/42),P<0.05;观察组新生儿不良结局发生率为14.29%(6/42),对照组发生率为35.71%(15/42),P<0.05;比较两组患者治疗前后的血清甲状腺激素水平,治疗之前患者之间没有差异,P>0.05,治疗以后6周,观察组明显优于对照组,P<0.05。结论对妊娠合并甲减的患者根据患者的血清甲状腺激素水平来确定左旋甲状腺素钠片的剂量进行治疗可以有效的提高患者的自然分娩率,降低妊娠合并症的发生率,改善新生儿不良结局,改善患者的血清甲状腺素水平,值得推广。
Objective To compare the clinical effects of different doses of levothyroxine sodium tablets in the treatment of pregnancy with hypothyroidism.Methods A total of 42 patients with pregnancy-induced hypothyroidism who came to our hospital from April 2017 to June 2019 were selected as the observation group.42 patients with pregnancy-induced hypothyroidism who were treated in our hospital for the same period were selected as the control group.The patients in the group were treated with levothyroxine tablets.The patients in the observation group were determined according to the serum thyroid hormone level of the patients.The dose of the control group was 125μg.The effects of the two groups were evaluated and compared.Results The natural delivery rate was 85.71%(36/42)in the observation group and 47.62%(20/42)in the control group,P<0.05.The incidence of pregnancy complications in the observation group was 28.57%(12/42).54.76%(23/42),P<0.05;the incidence of adverse neonatal outcomes in the observation group was 14.29%(6/42),and the incidence in the control group was 35.71%(15/42),P<0.05;there was no difference in serum thyroid hormone levels before and after treatment,P>0.05,6 weeks after treatment,the observation group was significantly better than the control group,P<0.05.Conclusion The treatment of patients with pregnancy-induced hypothyroidism according to the patient's serum thyroid hormone level to determine the dose of levothyroxine sodium tablets can effectively improve the patient's natural delivery rate,reduce the incidence of pregnancy complications,and improve neonatal adverse outcomes.To improve the serum thyroxine level of patients,it is worth promoting.
作者
庞雪静
PANG Xuejing(Department of Pharmacy,Chifeng No.2 Hospital,Chifeng 024000,China)
出处
《中国医药指南》
2021年第24期69-70,73,共3页
Guide of China Medicine
