摘要
目的对超出溶栓时间窗的急性缺血性脑卒中(AIS)患者采用替罗非班治疗的效果进行探究。方法选择2019年2月—2020年1月本院收治的超出溶栓时间窗AIS患者88例作为本次研究纳入的研究对象,按照随机数字表法将其划分为甲组(n=44)和乙组(n=44)。采用不同方式对两组患者进行治疗,对比两组患者的治疗效果。结果乙组的疗效明显高于甲组,差异有统计学意义(P<0.05);乙组的左右侧大脑中动脉、基底动脉血流指标优于甲组,差异有统计学意义(P<0.05)。治疗前,两组的神经功能缺损评分和日常生活能力评分相比差异无统计学意义(P>0.05);治疗后,乙组的神经功能缺损评分和日常生活能力评分均明显高于甲组,差异有统计学意义(P<0.05)。结论针对超出溶栓时间窗的AIS患者采用替罗非班治疗具有较好效果,能够有效改善患者的动脉血流情况,还可以改善患者的神经功能缺损症状,提高其日常生活能力。
Objective To explore the effect of tirofiban treatment in patients with acute ischemic stroke(AIS)beyond the thrombolytic time window.Methods A total of 88 patients with AIS beyond the time window of thrombolysis in our hospital from February 2019 to January 2020 were selected as the subjects of this study. According to the random number table method, they were divided into group A (n=44) and group B (n=44). The two groups of patients were treated in different ways, and the treatment effects of the two groups were compared. Results The curative effect of group B was significantly higher than that of group A (P<0.05);The blood flow indexes of left and right middle cerebral artery and basilar artery in group B were better than those in group A (P<0.05). Before treatment, there was no significant difference in neurological deficit score and ADL score between the two groups (P>0.05);After treatment, the scores of neurological deficit and ADL in group B were significantly higher than those in group A (P<0.05). Conclusion The use of tirofiban for AIS patients beyond the thrombolytic time window has a good effect. It can effectively improve the patient's arterial blood flow, and can also improve the patient's neurological deficit symptoms and improve their ability of daily living.
作者
孔琦
KONG Qi(Department of Neurolog,Anlu City Puai Hospital,Xiaogan Hubei 432600,China)
出处
《中国继续医学教育》
2021年第26期146-150,共5页
China Continuing Medical Education
关键词
溶栓时间窗
急性缺血性脑卒中
替罗非班
疗效
左右侧大脑中动脉
基底动脉
thrombolytic time window
acute ischemic stroke
tirofiban
curative effect
left and right middle cerebral artery
basilar artery
