摘要
目的针对老年肺炎患者采用桉柠蒎肠溶软胶囊联合头孢曲松钠进行治疗,旨在对其炎症指标的影响进行深入研究。方法选取该院2018年6月—2019年10月收治的老年肺炎患者75例纳入研究并随机编号1~75号,对照组中均为偶数号,观察组中均为奇数号,其中对照组37例,观察组38例。对照组采用头孢曲松钠治疗,观察组在对照组的基础上联合桉柠蒎肠溶软胶囊治疗,比较两组临床疗效及炎症因子水平。结果观察组患者临床总有效率(97.37%)明显高于对照组(78.38%),差异有统计学意义(P<0.05);治疗后两组患者肺表面活性剂脱辅基蛋白A(SP-A)、半胱氨酰白三烯(CysLTs)、血清白细胞介素-6(IL-6)、降钙素原(PCT)及C反应蛋白(CRP)水平均低于治疗前,差异有统计学意义(P<0.05);与对照组治疗后血清IL-6、CysLTs、SP-A、CRP及PCT水平[(38.16±6.17)ng/L,(0.79±0.09)μg/L、(22.64±7.68)μg/L、(14.45±1.38)mg/L、(4.95±0.76)ng/mL]相比,观察组[(25.37±5.23)ng/L,(0.64±0.07)μg/L,(18.55±6.73)μg/L,(6.74±1.27)mg/L,(1.23±0.19)ng/mL]较低,差异有统计学意义(t=9.693、8.069、2.455、25.187、29.254,P<0.05)。结论老年肺炎患者采用桉柠蒎肠溶软胶囊联合头孢曲松钠治疗的效果较好,可有效降低血清炎症因子水平。
Objective To treat elderly patients with pneumonia with eucalyptus and pine pin enteric-coated soft capsules combined with ceftriaxone sodium for in-depth study of the influence of inflammation indicators.Methods Seventy-five elderly patients with pneumonia admitted to the hospital from June 2018 to October 2019 were selected and randomly numbered 1-75.In the control group,all were even numbers,and the observation group were all odd numbers.Among them,the control group was 37 cases,38 cases in the observation group.The control group was treated with ceftriaxone sodium,and the observation group was treated with eucalyptus and pine pin enteric-coated soft capsules on the basis of the control group.The clinical efficacy and levels of inflammatory factors were compared between the two groups.Results The total clinical effective rate of 97.37%in the observation group was significantly higher than 78.38%in the control group,and the difference was statistically significant(P<0.05);after treatment,the two groups of patients had lung surfactant apoprotein A(SP-A),half Cysteinyl leukotrienes(CysLTs),serum interleukin-6(IL-6),procalcitonin(PCT)and C-reactive protein(CRP)levels were lower than before treatment,and the difference was statistically significant(P<0.05);Serum IL-6,CysLTs,SP-A,CRP and PCT levels after treatment with the control group[(38.16±6.17)ng/L,(0.79±0.09)μg/L,(22.64±7.68)μg/L,(14.45±1.38)mg/L,(4.95±0.76)ng/mL]compared with the observation group[(25.37±5.23)ng/L,(0.64±0.07)μg/L,(18.55±6.73)μg/L,(6.74±1.27)mg/L,(1.23±0.19)ng/mL]was low,the difference was statistically significant(t=9.693,8.069,2.455,25.187,29.254,P<0.05).Conclusion The treatment of elderly patients with pneumonia with eucalyptus and pine pin enteric-coated soft capsules combined with ceftriaxone sodium can effectively reduce the level of serum inflammatory factors.
作者
侯剑梅
范智彦
徐阳
HOU Jianmei;FAN Zhiyan;XU Yang(Department of Clinical Pharmacy,Lanling County Hospital of Traditional Chinese Medicine,Linyi,Shandong Province,277700 China;Department of Pharmacy,the Third People's Hospital of Linyi City,Linyi,Shandong Province,276023 China;Department of Pharmacy,Lanling County Hospital of Traditional Chinese Medicine,Linyi,Shandong Province,277700 China)
出处
《系统医学》
2021年第11期162-164,共3页
Systems Medicine
关键词
老年肺炎
桉柠蒎肠溶软胶囊
头孢曲松钠
炎症指标
Senile pneumonia
Eucalyptus and pine pin enteric-coated soft capsules
Ceftriaxone sodium
Inflammation indicators
