摘要
血管生成素样蛋白(ANGPTLs)是一类与血管生成素结构相似的分泌型糖蛋白,其在实体肿瘤的侵袭转移、血管生成、细胞凋亡等过程中发挥重要的调节作用。局部乏氧是肿瘤微环境最突出的特征,其介导多个生物学过程,进而影响肿瘤的进展以及治疗效果。ANGPTLs家族中的部分蛋白可作为乏氧诱导因子1的下游靶基因,调节肿瘤的生理功能。因此,阐明ANGPTLs在肿瘤中的作用及其机制对提高肿瘤治愈率和改善患者预后具有重要意义。笔者概述了ANGPTLs家族的生物学特征、在肿瘤发生发展以及肿瘤乏氧微环境中可能的作用。
Angiopoietin-like proteins(ANGPTLs),a class of secreted glycoproteins with a similar structure to angiopoietin,play a pivotal role in solid tumors invasion,metastasis,angiogenesis and apoptosis.As the prominent feature of the tumor microenvironment,hypoxia affects tumor progression and therapeutic effect through mediating multiple biological processes.Some ANGPTLs can act as downstream target genes of hypoxia-inducible factor 1 to regulate tumor physiological functions.Therefore,elucidating the effect and mechanism of ANGPTLs in tumor is of essential significance for improving the tumor cure rate and prognosis.In this article,a brief outline of the biological characteristics of the ANGPTLs family and their possible roles in tumorigenesis,development and hypoxic microenviroment is presented.
作者
张育红
邵春林
张江虹
Zhang Yuhong;Shao Chunlin;Zhang Jianghong(Department of Radiation Biology,Institute of Radiation Medicine,Fudan University,Shanghai 200032,China)
出处
《国际放射医学核医学杂志》
2021年第6期403-408,共6页
International Journal of Radiation Medicine and Nuclear Medicine
基金
国家自然科学基金(81672985、31770910)。
