摘要
目的观察黄芪注射液足三里穴位注射治疗肺脾气虚型慢性阻塞性肺疾病(COPD)稳定期的临床疗效。方法采用随机、双盲、对照研究,收集肺脾气虚型COPD稳定期患者95例,治疗组48例、对照组47例。其中治疗组采用舒利迭联合黄芪注射液足三里注射,对照组采用舒利迭联合生理盐水足三里注射,双侧足三里,每周2次,疗程为12周。观察2组患者治疗前后肺功能、急性发作次数变化情况,同时,对多个时间点的临床疗效进行评估。结果2组患者肺功能(FEV_(1)%、FEV_(1)/FVC%)治疗前后比较均差异有统计学意义(P<0.05);治疗后2组患者肺功能(FEV_(1)%、FEV_(1)/FVC%)较对照组改善明显,但组间比较差异无统计学意义(P>0.05)。治疗后2组急性发作次数比较,差异有统计学意义(P<0.05),治疗组临床疗效优于对照组。治疗组中医症状在第3周开始显效,对照组中医症状在第2周开始显效;2组患者中医症状比较在第9周差异有统计学意义(P<0.05),治疗组疗效明显优于对照组。结论黄芪注射液足三里穴位注射能够有效改善COPD稳定期患者肺功能及临床症状、减少急性发作次数,延长穴位注射治疗周期,有助于提高临床疗效,且安全可靠,值得在临床中推广。
Objective To observe the clinical effect of Huangqi acupoint injection in the treatment of stable chronic obstructive pulmonary disease with qi deficiency of lung and spleen type.Methods A randomized,double-blind,controlled study was conducted in the study,nitnty-five patients with stable chronic obstructive pulmonary disease(COPD)were divided into two groups,and the syndrome differentiation type was qi deficiency of lung and spleen,with 48 patients in the treatment group and 47 patients in the control group.The treatment group was treated by Seretide combined with Huangqi acupoint injection on Zusanli(ST36),while the control group was given Seretide combined with physiological saline injection at Zusanli(ST36),bilateral Zusanli(ST36),and twice a week for 12 weeks.The changes of pulmonary function and acute attack frequency were observed before and after treatment.At the same time,the clinical efficacy of multiple time points was evaluated.Results The lung function(FEV_(1)%,FEV_(1)/FVC%)of the two groups before and after treatment were statistically different(P<0.05).After treatment,the lung function(FEV_(1)%,FEV_(1)/FVC%)of the two groups were significantly improved,but there was no significant difference between the two groups(P>0.05).After treatment,there was a significant difference in the number of acute attacks between the two groups(P<0.05),and the curative effect of the treatment group was better than that of the control group.The traditional Chinese medicine symptoms of the treatment group began to show effect in the third week,while the control group began to show significant effect in the second week.The traditional Chinese medicine symptoms of the two groups showed statistical significance at the 9 th week(P<0.05),and the curative effect of the treatment group was better than that of the control group.Conclusion Huangqi acupoint injection on Zusanli(ST36)can effectively improve the lung function of stable COPD patients,and reduce the number of acute attack.Prolonging the treatment cycle of acupoint injection is helpful to improve the clinical efficacy,and it is safe and reliable,which is worthy of promotion in clinical practice.
作者
张秀莲
危蕾
黄品贤
刘芳英
钱叶长
ZHANG Xiulian;WEI Lei;HUANG Pinxian;LIU Fangying;QIAN Yechang(Department of Respiratory Medicine,Baoshan Branch of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200473,China;Department of Respiratory Medicine,Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai 200437,China)
出处
《光明中医》
2021年第16期2722-2726,共5页
GUANGMING JOURNAL OF CHINESE MEDICINE
基金
上海市卫生和计划生育委员会中医药科研项目(No.2018LQ001)
上海市科学技术委员会科研计划项目(No.19401933200)
上海中医大学后备卓越中医人才项目。
关键词
肺脾气虚证
慢性阻塞性肺疾病
黄芪注射液
穴位注射
lung spleen qi deficiency syndrome
chronic obstructive pulmonary disease
Huangqi injection
acupoint injection
