摘要
目的:探究2型糖尿病(type 2 diabetes mellitus,T2DM)女性患者骨质疏松症(osteoporosis,OP)现况及其相关因素,为预防OP提供科学依据。方法:选取2018年12月-2019年12月北京大学深圳医院内分泌科收治的T2DM女性患者257例,采用双能X线骨密度仪测定腰椎L_(1~4)、股骨及股骨颈骨密度(bone mineral density,BMD)。以T值为标准分为三组:骨量正常组(T≥-1.0)、骨量减少组(-2.5<T<-1.0)和骨质疏松组(T≤-2.5),比较三组生化指标、年龄、BMI等,采用logistic回归分析OP患病相关因素。结果:T2DM女性患者OP患病率为26.3%。三组年龄、DM病程、BMI比较,差异均有统计学意义(P<0.05)。logistic回归分析示,≥65岁、绝经均是T2DM女性OP的危险因素[OR=2.227,95%CI(1.160,4.276),P=0.016;OR=10.716,95%CI(2.412,47.610),P=0.002]。结论:T2DM女性患者OP患病率高,尤其是绝经的老年女性。
Objective:To investigate the prevalence and influence factors of osteoporosis(OP)of female patients with type 2 diabetes mellitus(T2DM)and provide scientific basis for prevention of OP.Method:A total of 257 female patients with T2DM admitted to the Department of Endocrinology,Shenzhen Hospital of Peking University from December 2018 to December 2019 were selected,bone mineral density(BMD)was measured by dual energy X-ray bone mineral density instrument at the lumbar vertebrae L1-4,femur and femoral neck.According to the degree of T-score,patients were divided into three groups:normal bone mass group(T≥-1.0 SD),decreased bone mass group(-2.5 SD<T<-1.0 SD),osteoporosis group(T≤-2.5 SD).Laboratory results,age,BMI and so on were compared among three groups.logistic regressions analysis was used to analyze its influence factors.Result:The prevalence of OP of female patients with T2DM was 26.3%.There were significant differences between various state of age,course of DM,BMI(P<0.05).logistic regression analysis showed that:≥65 years old[OR=2.227,95%CI(1.160,4.276),P=0.016]and menopause[OR=10.716,95%CI(2.412,47.610),P=0.002]were risk factors for OP in the female patients with T2DM.Conclusion:The prevalence of OP of female patients with T2DM is higher,especially postmenopausal elderly women.
作者
谭晓霞
洪丽荣
连晓芬
曾庆祥
黄政杰
谢凤
张帆
TAN Xiaoxia;HONG Lirong;LIAN Xiaofen;ZENG Qingxiang;HUANG Zhengjie;XIE Feng;ZHANG Fan(Perking University Shenzhen Hospital,Shenzhen 518000,China;不详)
出处
《中国医学创新》
CAS
2021年第21期138-141,共4页
Medical Innovation of China
基金
广东省高水平医院重点建设医院专项项目(粤办函[2019]260号)
深圳市科创委知识创新计划基础研究项目专项课题(深发改[2017]1447)
重大慢性非传染性疾病防控研究项目(2017YFC1310704)。
关键词
2型糖尿病
女性
骨质疏松症
Type 2 diabetes mellitus
Female
Osteoporosis
