摘要
目的:观察中西医结合治疗肾虚肝郁型早发性卵巢功能不全的临床疗效。方法:84例肾虚肝郁型早发性卵巢功能不全患者按掷硬币法分为对照组和观察组,各42例。对照组给予戊酸雌二醇片(商品名克龄蒙)治疗;观察组在对照组治疗基础上给予毓坤汤。比较两组患者临床疗效,中医证候评分,卵泡刺激素(follicle-stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)水平,妇科超声指标。结果:治疗后,观察组有效率为95.24%,对照组有效率为79.19%,两组比较,差异有统计学意义(P<0.05)。治疗后,两组患者月经停闭、腰膝酸软、抑郁易怒、烘热汗出评分均低于治疗前,且观察组以上指标评分均低于同期对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者FSH、LH水平均低于治疗前,且观察组以上指标评分均低于同期对照组,差异均有统计学意义(P<0.05);两组患者雌二醇水平均高于治疗前,且观察组雌二醇水平高于同期对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者子宫内膜厚度、卵巢直径、卵巢动脉收缩期血流峰值流速均高于治疗前,且观察组以上指标高于同期对照组,差异均有统计学意义(P<0.05)。结论:毓坤汤联合克龄蒙治疗肾虚肝郁型早发性卵巢功能不全疗效显著,可显著降低月经停闭、腰膝酸软、抑郁易怒、烘热汗出评分,FSH、LH水平;提高雌二醇水平,子宫内膜厚度、卵巢直径、卵巢动脉收缩期血流峰值流速。
Objective:To observe the clinical effect of integrated traditional Chinese and western medicine in treating premature ovarian insufficiency(POI)of Kidney deficiency and Liver depression.Methods:A total of 84 POI patients with Kidney deficiency and Liver depression were divided into control group and observation group by coin toss,with 42 cases in each.The control group was treated with estradiol valerate tablets(Kelingmeng),and the observation group was treated with Yukun Decoction on the basis of the control group treatment.The clinical efficacy,TCM syndrome scores,follicle-stimulating hormone(FSH),luteinizing hormone(LH)levels,and gynecological ultrasound indexes were compared between the two groups.Results:After treatment,the effective rate of the observation group was 95.24%,and the effective rate of the control group was 79.19%.The difference between the two groups was statistically significant(P<0.05).After treatment,the scores of menstrual cessations,soreness of the waist and knees,depression,irritability,and sweating of the two groups were lower than those before treatment,and the scores of the above indicators in the observation group were lower than those of the control group during the same period,and the differences were statistically significant(P<0.05).After treatment,the FSH and LH levels of the two groups of patients were lower than before treatment,and the scores of the above indicators in the observation group were lower than those of the control group during the same period,the difference was statistically significant(P<0.05).The estradiol level of the two groups of patients was higher after treatment,which the observation group was higher than that of the control group during the same period,the difference was statistically significant(P<0.05).After treatment,the endometrial thickness,ovarian diameter,and PSV in the two groups were higher,and the above indicators in the observation group were higher than those in the control group during the same period.The differences were statistically significant(P<0.05).Conclusion:Yukun Decoction combined with Kelingmeng has a significant effect on the treatment of Kidney deficiency and Liver depression POI,and can significantly reduce menstrual cessation,waist and knee weakness,depression,irritability,heat,and sweat score,FSH and LH levels.It also increases the level of estradiol,the thickness of the endometrium,the diameter of the ovary,and PSV.
作者
苑帆
郭华林
徐颜红
YUAN Fan;GUO Hualin;XU Yanhong(Xuchang Central Hospital,Xuchang Henan China 461000;Henan Institute of Reproductive Health Science and Technology,Zhengzhou Henan China 450002)
出处
《中医学报》
CAS
2021年第10期2233-2238,共6页
Acta Chinese Medicine
基金
许昌市科技攻关项目(20170213258)。
