摘要
山楂为蔷薇科植物山里红或山楂的干燥成熟果实,临床应用广泛。《龚廷贤医学全书》载含山楂的方剂共纳入116首,用药总频数达1618次,主治疾病35种。龚氏用药较为集中,组方思路清晰,临证选药,特色鲜明,常将山楂与补虚药、利水渗湿药、理气药、消食药相伍,其中频数较高的前四项药物依次为白术、茯苓、甘草、陈皮,多用"山楂-白术"消解肠胃食积而不伤正,用于治疗伤食和疳疾;"山楂-茯苓"消积又有渗湿以解肠腑困阻之效,用于治疗痢疾;"山楂-陈皮"行气散瘀,用于治疗积聚。对高频病症进行用药关联规则和复杂网络分析,可得出山楂治疗高频病症的多个核心药物组合,既强调补益脾胃之法,亦注重疏通壅滞。本研究以山楂为切入点,运用数据挖掘技术,科学地、直观地、多角度地探讨了龚廷贤医家的临床应用山楂学术经验,总结其诊治思想,以期为临床用药提供一定指导,并对其学术思想的继承及新药研发提供参考。
Shanzha(Crataegus pin.nafi fida Bge.)is the dry and mature fruit of rosaceae plant Shanlihong(Crataegus pinnafifida Var.majo N.E.Brown)or hawthorn,which is widely applied in clinical practice.Gong Tingxian Yixue Quanshu(《龚廷贤医学全书》)contains 116 prescriptions containing Shanzha,with a total frequency of 1618 times,and 35 kinds of diseases suitable for treating with Shanzha.Gong’s medication is more concentrated,the thought of formulation is clear.Shanzha is often compatible with tonic medicines,diuretic and dampness medicines,Qi-regulating medicines,or promoting digestion medicines.Among them,the top 4 medicines with higher frequency are Baizhu(Atractylodes macrocephala Koidz.),Fuling(Poria cocos(Schw.)wolf),Gancao(Glycyrrhiza uralensis Fish),and Chenpi(Pericarpium Citri Reticulatae).“Shanzha-Baizhu”medicine pair is often used to dissolve gastrointestinal accumulation without hurting the body,and is applied in treating food injury and chancre.“Shanzha-Fuling”medicine pair shows the effect of eliminating dampness to relieve intestinal obstruction,and is applied to treat dysentery.“Shanzha-Chenpi”medicine pair shows the effects of promoting Qi(气)and dispersing blood stasis,and is applied to treat accumulation.The results of medication association rules and complex network analysis showed that Shanzha has multiple core medicines combinations for the treatment of high-frequency diseases,emphasizing not only the method of replenishing the spleen and stomach,but also the clearing of stagnation.In this study,Dr.Gong Tingxian’academic experience in applying Shanzha was scientifically,intuitively and multi-anglely explored based on data mining technology,and his diagnosis and treatment ideas were summarized,it is expected to provide certain guidances for clinical medication,and provide more references for the inheritance of his academic ideas and the research and development of new medicines.
出处
《中医临床研究》
2021年第17期19-25,共7页
Clinical Journal Of Chinese Medicine
基金
江西省重点研发计划项目(20201BBG71005)
江西省自然科学基金项目(20202BABL216072)
江西省药品监督管理局科研项目(2019SJ20)
江西中医药大学博士启动基金(2018WBZR016)。
