摘要
目的分析阿维A胶囊联合中医治疗红皮病型银屑病的效果。方法选取2018年2月至2020年8月日照市皮肤病防治所皮肤科收治的红皮病型银屑病患者82例作为研究对象,依据随机数字表法分为对照组和研究组,每组41例。对照组给予阿维A胶囊治疗,研究组给予阿维A胶囊联合中医治疗,比较两组的临床治疗效果、不良反应以及银屑病面积与严重性指数(PASI)积分。结果研究组治疗总有效率为92.68%,高于对照组的70.73%,组间比较,差异有统计学意义(χ^(2)=6.609,P<0.05);研究组不良反应发生率为17.07%,明显低于对照组的46.34%,差异有统计学意义(χ^(2)=6.963,P<0.05);治疗前,两组患者的PASI积分比较,差异无统计学意义(P>0.05),治疗4周、8周后,研究组的PASI积分明显低于对照组,差异有统计学意义(P<0.05)。结论在红皮病型银屑病的治疗中,阿维A胶囊联合中医治疗效果更加明显,且不良反应少,具有非常高的安全性,值得在临床中进一步推广和使用。
Objective Analyze the effect of Acitretin capsules combined with Chinese medicine in the treatment of erythrodermic psoriasis.Methods From February 2018 to August 2020,82 patients with erythrodermic psoriasis admitted to the Dermatological Department,Skin Disease Prevention and Control of Rizhao and were selected as the research objects.According to the random number table method,they were divided into control group and study group,each with 41 example.The control group was treated with Acitretin capsules,and the study group was treated with Acitretin capsules combined with traditional Chinese medicine.The clinical treatment effects of the two groups were compared,adverse reactions,and psoriasis area and severity index(PASI)scores.Results The total effective rate of treatment in the study group was 92.68%,which was higher than 70.73%in the control group.The difference between the groups was statistically significant(χ^(2)=6.609,P<0.05);the adverse reaction rate in the study group was 17.07%,which was significantly lower than the control group 46.34%of the group,the difference was statistically significant(χ^(2)=6.963,P<0.05);before treatment,the difference in PASI scores between the two groups of patients was not statistically significant(P>0.05),after 4 weeks and 8 weeks of treatment,The PASI score of the study group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of erythroderma-type psoriasis,Acitretin capsule combined with traditional Chinese medicine has more obvious therapeutic effects,and has fewer adverse reactions,and has very high safety.It is worthy of further promotion and use in clinical practice.
作者
王云鹏
宋艳霞
王桂伟
杨瑞海
WANG Yunpeng;SONG Yanxia;WANG Guiwei;YANG Ruihai(Dermatological Department,Skin Disease Prevention and Control of Rizhao,Rizhao,Shandong 276801,China)
出处
《大医生》
2021年第10期8-10,共3页
Doctor
关键词
红皮病型银屑病
阿维A胶囊
中医
erythrodermic psoriasis
acitretin capsules
traditional chinese medicine
