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乳腺癌中p53、EGFR表达及与病理分期、组织学分级的关系

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摘要 目的:研究乳腺癌中肿瘤抑制蛋白(p53)、表皮生长因子受体(EGFR)表达与病理分期、组织学分级的关系。方法:选取2018年1月~2020年7月开封市妇产医院病理科100例乳腺癌患者术后病理组织行免疫组化,观察组织内p53、EGFR表达情况;收集患者临床资料,采用Spearman相关性分析p53、EGFR表达与病理参数关系。结果:经Spearman相关性分析显示,p53突变型和EGFR阳性者与肿瘤大小、淋巴转移、病理组织学分级呈正相关(P<0.05)。结论:p53、EGFR在乳腺癌中呈高表达,与患者病理组织学分级等病理特征呈正相关,可对患者预后提供一定判断。
出处 《实用中西医结合临床》 2021年第17期49-50,共2页 Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
基金 河南省自然科学基金(编号:202300410326) 河南省医学科技攻关计划项目(编号:LHGJ20190452)。
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