摘要
目的:分析重症肺炎患儿血清细胞因子动态变化与预后的相关性。方法:2019年1月-2020年6月收治重症肺炎患儿120例,按病程第7天转归情况划分为好转组和恶化组。两组患儿均于病程第1天、第3天及第7天测定血清白介素-6(IL-6)、白介素-10(IL-10)及肿瘤坏死因子-α(TNF-α)水平;所有患儿均进行重症肺炎预后PORT评分(PSI),并分析各病程时段炎症细胞因子水平与PSI评分之间的相关性。结果:好转组病程第3天和第7天的血清IL-6、IL-10及TNF-α水平均低于恶化组,差异有统计学意义(P<0.05)。好转组病程第3天和第7天的PSI评分均低于恶化组,差异有统计学意义(P<0.05)。重症肺炎患儿血清细胞因子水平与PSI评分呈明显正相关。结论:监测重症肺炎患儿的血清细胞因子动态变化,能够较准确判断病情演变,并为有效地治疗及判断预后提供可靠依据。
Objective:To analyze the correlation between the dynamic changes of serum cytokines and prognosis in children with severe pneumonia.Methods:From January 2019 to June 2020,120 children with severe pneumonia were selected and divided into two groups,improved group and worsening group according to the outcome at the 7 th day of the course of disease.Serum levels of IL-6,IL-10 and TNF-αwere measured on the 1 st,3 rd and 7 th day of the course of disease in both groups.Prognostic PORT score(PSI)was performed for all patients with severe pneumonia,and the correlation between the levels of inflammatory cytokines and PSI score was analyzed at different stages of the disease.Results:The levels of serum IL-6,IL-10 and TNF-αin the improved group were lower than the worsening group on the 3 rd and 7 th day of the course of disease,with the differences were statistically significant(P<0.05).PSI scores of the improved group were lower than the worsening group on the 3 rd and 7 th day of the course of disease,with the differences were statistically significant(P<0.05).Serum cytokine levels were positively correlated with PSI scores in children with severe pneumonia.Conclusion:Monitoring the dynamic changes of serum cytokines in children with severe pneumonia can accurately judge the disease evolution,and provide reliable basis for effective treatment and prognosis judgment.
作者
李宏颖
齐玥莹
Li Hongying;Qi Yueying(The Hospital of Tongliao City,Inner Mongolia,Neimenggu Tongliao 028000)
出处
《中国社区医师》
2021年第27期115-116,共2页
Chinese Community Doctors
关键词
儿童重症肺炎
炎症细胞因子
PSI评分
预后
Severe pneumonia in children
Inflammatory cytokines
PSI score
Prognosis
