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神经节苷脂注射液联合依达拉奉注射液治疗未溶栓急性脑梗死患者的效果观察及对认知功能、日常生活能力的影响 被引量:23

Effectiveness of Ganglioside Injection Combined with Edaravone Injection in Treatment of Patients with Acute Cerebral Infarction without Undergoing Thrombolysis and Its Effects on Cognitive Function and Activities of Daily Living
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摘要 目的探讨神经节苷脂注射液联合依达拉奉注射液治疗未溶栓急性脑梗死(ACI)患者的效果及对认知功能、日常生活能力的影响。方法选取2019年2月—2020年8月我院收治的未溶栓ACI患者113例,据治疗方法的不同分为研究组59例和对照组54例,对照组在常规对症支持治疗基础上加用依达拉奉注射液治疗,研究组在对照组基础上联合神经节苷脂注射液治疗,2组均连续治疗2周。比较2组治疗前及治疗后1 d神经功能缺损情况[美国国立卫生研究院卒中量表(NIHSS)评分]、认知功能障碍程度[简易精神状态评价量表(MMSE)评分]、日常生活能力(Barthel指数评分)及治疗期间不良反应发生情况。结果治疗2周后,研究组总有效率显著高于对照组(P<0.01);治疗后,2组NIHSS评分较治疗前降低,MMSE评分及Barthel指数评分较治疗前升高,且研究组上述指标改善程度更大,差异有统计学意义(P<0.01);治疗期间2组总不良反应发生率比较差异无统计学意义(P>0.05)。结论神经节苷脂注射液联合依达拉奉注射液治疗未溶栓ACI患者可有效提高临床效果,减轻脑神经损伤程度,改善认知功能障碍和日常生活能力,且应用安全性高。 Objective To investigate the effectiveness of Ganglioside Injection combined with Edaravone Injection in treatment of patients with acute cerebral infarction(ACI)without undergoing thrombolysis and its effects on cognitive function and activities of daily living(ADL).Methods A total of 113 ACI patients without undergoing thrombolysis admitted between February 2019 and Augest 2020 were selected and divided into research group(n=59)and control group(n=54)according to different therapeutic methods.Control group was treated with Edaravone Injection on the basis of routine symptomatic support treatment,while research group was added with Ganglioside Injection on the basis of treatment for control group.Both groups were continuously treated for 2 weeks.Condition of neurologic impairment[National Institutes of Health Stroke Scale(NIHSS)score],degree of cognitive dysfunction[Mini Mental State Evaluation Scale(MMSE)score],the ADL(Barthel index score)before and after treatment for 1 d and incidence rate of adverse reactions during the treatment were compared between two groups.Results After treatment for 2 week,the total effective rate in research group was significantly higher than that in control group(P<0.01).After treatment,NIHSS scores were significantly lower,while MMSE and Barthel index scores were significantly higher than those before treatment in two groups,and the improvement degrees of the above indexes in research group were more significant(P<0.01).There was no significant difference in the total incidence rate of adverse reactions during treatment between two groups(P>0.05).Conclusion Ganglioside Injection combined with Edaravone Injection in treatment of ACI patients without undergoing thrombolysis may effectively improve clinical effectiveness,reduce the degree of brain nerve injury,and improve the cognitive dysfunction and ADL with good safety.
作者 石小翠 胡美云 杜寨 宋佳 SHI Xiao-cui;HU Mei-yun;DU Zhai;SONG Jia(Department of Neurology,the Central Hospital of Handan City,Handan,Hebei 056000,China;Department of Gastroenterology,Anguo Hospital,Anguo,Hebei 071200,China)
出处 《解放军医药杂志》 CAS 2021年第9期101-105,共5页 Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金 河北省医学研究重点计划项目(20171132)。
关键词 脑梗死 神经节苷脂注射液 依达拉奉注射液 BARTHEL指数 药物毒性 Brain infarction Ganglioside injection Edaravone injection Barthel index Drug toxicity
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