摘要
目的探讨间歇血液透析(IHD)与连续血液透析(CBP)治疗急性肾衰竭的效果及对患者毒素清除率和肾功能指标的影响。方法选取2018年1月至2019年11月大连市友谊医院收治的急性肾衰竭患者78例为研究对象,随机单双数法分为对照组39例,接受间歇性血液透析;观察组39例为连续血液透析,对比两种透析方式下患者治疗效果、毒素清除率和肾功能、血气指标等状况。结果观察组患者治疗后临床总有效率高于对照组,差异有统计学意义(P<0.05);观察组患者血钾、血磷毒素清除率高于对照组,差异有统计学意义(P<0.05);治疗前两组患者血尿素氮(BUN)等指标相近,而治疗后观察组患者肾功能指标BUN、血清肌酐(SCr)、血清胱抑素C(CysC)等,均优于对照组,差异有统计学意义(P<0.05);治疗前两组患者血气指标相近(P>0.05);治疗后患者血气指标均优于对照组,差异有统计学意义(P<0.05);观察组患者炎症反应指标治疗后优于对照组,差异有统计学意义(P<0.05)。结论IHD与CBP应用于治疗急性肾衰竭,可有效提升疾病总有效率,毒素清除率,改善肾功能和血气指标,控制炎症反应,有临床应用价值。
Objective To exprole the effect of intermittent hemodialysis(IHD)and continuous hemodialysis(CBP)in the treatment of acute renal failure(ARF)and the effects on the clearance rate of toxins and renal function indexes.Methods Seventy and eight patients with acute renal failure in Dalian Friendship Hospital from January 2018 to November 2019 were selected and randomly divided into control group(39 cases)and observation group(39 cases)by single and even number method.The control group received indirect hemodialysis,and the observation group received continuous hemodialysis.The treatment effect,toxin clearance rate,renal function,blood gas index and other conditions were compared between the two dialysis methods.Results After treatment,the clinical total effective rate of the observation group was higher than that of the control group(P<0.05);the clearance rate of serum potassium and phosphorus toxin in the observation group was higher than that in the control group,the difference was significant(P<0.05).Before treatment,bun(blood urea nitrogen)and other indicators of the two groups were similar);after treatment,the renal function indexes of the observation group were BUN,SCR and CysC in the observation group were better than those in the control group(P<0.05).Before treatment,the blood gas indexes of the two groups were similar(P>0.05);after treatment,the blood gas indexes of the patients in the observation group were better than those in the control group(P<0.05);the inflammatory reaction indexes of the observation group were better than those of the control group(P<0.05).Conclusions IHD and CBP for patients with acute renal failure can effectively improve the total effective rate,toxin clearance rate,improve renal function and blood gas indicators,control inflammatory reaction,and has clinical application value.
作者
赵春莉
曹昌萌
柳颖
李纯
安萌萌
董志扬
刘菲
Zhao Chunli;Cao Changmeng;Liu Ying;Li Chun;An Mengmeng;Dong Zhiyang;Liu Fei(Department of Critical Care Medicine,Dalian Friendship Hospital,Dalian 116001,China)
出处
《中国临床保健杂志》
CAS
2021年第5期671-674,共4页
Chinese Journal of Clinical Healthcare
基金
辽宁省大连市医学科学研究计划项目(1711034)。
