摘要
目的观察不可手术的晚期胰腺癌患者采用γ射线体部立体定向放射治疗的效果。方法将接受直线加速器X射线常规三维适形放射治疗(3D-CRT)的45例患者纳入对照组;同期将接受γ射线体部立体定向放射治疗的45例患者纳入观察组。观察2组治疗5周时临床疗效,比较2组治疗前(T_(0))、治疗1周(T_(1))、治疗3周(T_(2))、治疗5周(T_(3))时的疼痛程度[采用数字疼痛分级法(NRS)评估]、肿瘤标志物糖类抗原19-9(CA19-9)水平,统计患者治疗期间不良反应发生情况及治疗后1年生存情况。结果观察组整体治疗效果优于对照组,且临床有效率高于对照组(P<0.05)。2组T_(1)、T_(2)、T_(3)时NRS评分较T_(0)时降低,且观察组低于对照组(P<0.05)。2组T_(1)、T_(2)、T_(3)时CA19-9水平均较T_(0)时降低,且观察组低于对照组(P<0.05)。观察组治疗期间不良反应发生率较对照组低,治疗后1年生存率高于对照组(P<0.05)。结论晚期胰腺癌患者采用γ射线体部立体定向放射治疗效果较好,可缓解癌痛程度,调节血清肿瘤标志物水平,不良反应较少,安全性好,可提高患者短期生存率。
Objective To observe the effect ofγray stereotactic radiotherapy therapy in the treatment of unresectable advanced pancreatic cancer.Methods The data of 45 patients who received conventional three-dimensional conformal radiotherapy therapy(3 D-CRT)were retrospectively analyzed and included into the control group;the data of 45 patients who receivedγray stereotactic radiotherapy therapy at the same time were included in the observation group.The clinical effects of the 2 groups were observed after 5 weeks of treatment,the pain degree[assessed by numerical rating scale(NRS)]and tumor markers[carbohydrate antigen 19-9(CA19-9)levels]before treatment(T_(0)),1 week(T_(1)),3 weeks(T_(2))and 5 weeks(T_(3))of treatment were compared between the 2 groups,the occurrence of adverse reactions pf patients during treatment and 1-year survival after treatment were counted.Results The overall treatment effect of the observation group was better than the control group,and the clinical effective rate was higher than the control group(P<0.05);the NRS scores at T_(1),T_(2)and T_(3)of both groups were lower than those at T_(0),and the observation group was lower than the control group(P<0.05);the level of CA19-9 at T_(1),T_(2)and T_(3)of both groups was lower than that at T_(0),and the observation group was lower than the control group(P<0.05);the incidence of side and toxic effects in the observation group was lower than the control group,and the 1-year survival rate was higher than the control group(P<0.05).Conclusionγray stereotactic radiotherapy has better treatment effect in patients with advanced pancreatic cancer,it can relieve cancer pain and regulate the level of serum tumor markers,has fewer side effects,high safety,and can improve the short-term survival rate of patients.
作者
赵娜
齐高强
张晶芳
ZHAO Na;QI Gaoqiang;ZHANG Jingfang(988th Hospital of Joint Logistic Support Force,Zhengzhou,450000)
出处
《实用癌症杂志》
2021年第8期1333-1336,共4页
The Practical Journal of Cancer
