摘要
目的:观察贞芪扶正颗粒联合微波疗法在尖锐湿疣患者治疗中的临床疗效。方法:采用随机数字表法将100例尖锐湿疣患者随机分为对照组与试验组各50例。对照组给予微波疗法治疗,试验组给予微波疗法^(+)贞芪扶正颗粒治疗。对比2组临床疗效;比较2组治疗前后粒细胞-巨噬细胞克隆刺激因子(GM-CSF)、脂质过氧化物(Lpo)水平及CD3^(+)、CD4^(+)/CD8^(+)变化情况;随访3个月,对比2组复发率。结果:试验组治疗总有效率为94.0%,高于对照组的80.0%(P<0.05)。与同组治疗前比较,治疗后2组血清GM-CSF、Lpo水平降低(P<0.05),CD3^(+)、CD4^(+)/CD8^(+)水平升高(P<0.05)。与对照组治疗后比较,试验组治疗后血清GM-CSF、Lpo水平更低(P<0.05),CD3^(+)、CD4^(+)/CD8^(+)水平更高(P<0.05)。试验组复发率为8.5%,低于对照组的30.0%(P<0.05)。结论:贞芪扶正颗粒联合微波疗法可通过下调相关炎症因子、增强患者的免疫功能治疗尖锐湿疣,其效果显著、复发率低。
Objective:To observe the clinical effect of Zhenqi Fuzheng granules combined with microwave therapy for condyloma acuminate.Methods:A total of 100 cases of patients with condyloma acuminate were divided into the control group and the experiment group according to the random number table method,50 cases in each group.The control group was treated with microwave therapy,and the experiment group was treated with Zhenqi Fuzheng granules and microwave therapy.The clinical effect was compared between the two groups.Before and after treatment,changes in levels of granulocyte macrophage colony-stimulating factor(GM-CSF) and lipid peroxide(Lpo),CD3^(+),and CD4^(+)/CD8^(+)were compared between the two groups.During three-month follow-up,the recurrence rate was compared between the two groups.Results:The total effective rate was 94.0%in the experiment group,higher than that of 80.0%in the control group(P<0.05).When compared with those in the same group before treatment,levels of GM-CSF and Lpo in serum in the two groups were decreased after treatment(P<0.05),and levels of CD3^(+)and CD4^(+)/CD8^(+)were increased(P<0.05).After treatment,levels of GM-CSF and Lpo in serum in the experiment group were lower than those in the control group(P<0.05),and levels of CD3^(+)and CD4^(+)/CD8^(+)were higher(P<0.05).The recurrence rate was 8.5%in the experiment group,lower than that of 30.0%in the control group(P<0.05).Conclusion:The therapy of Zhenqi Fuzheng granules combined with microwave therapy can treat condyloma acuminate by down-regulating relevant inflammatory factors and enhancing patients’immune function,with a significant effect and low recurrence rate.
作者
聂勇
吕哲
NIE Yong;LYU Zhe
出处
《新中医》
CAS
2021年第17期133-136,共4页
New Chinese Medicine
