摘要
目的考察康复新液联合四联疗法治疗幽门螺杆菌阳性胃溃疡的临床疗效。方法选择2019年2月—2020年2月在河南大学淮河医院就诊治疗的60例幽门螺杆菌阳性胃溃疡患者,按照入院先后顺序分为对照组和治疗组,每组各30例。对照组患者采用四联疗法治疗:口服阿莫西林胶囊,1.0 g/次,2次/d;口服克拉霉素缓释片,0.5 g/次,2次/d;口服枸橼酸铋钾颗粒,4袋/d,3餐前1袋,晚餐2 h后服用1袋;口服泮托拉唑钠肠溶胶囊,40 mg/次,2次/d;治疗2周后停用其他药物,仅口服泮托拉唑钠肠溶胶囊。治疗组患者在对照组治疗的基础上口服康复新液,10~15 m L/次,1次/d。两组连续治疗6周。观察两组患者临床疗效,比较两组治疗前后的血清氧化应激因子、炎性因子、胃肠道激素水平。结果治疗后,治疗组总有效率(93.33%)较对照组(76.67%)高,组间有差异(P<0.05)。治疗后,两组患者的丙二醛(MDA)、脂质过氧化物(LPO)水平与同组治疗前数据相比较显著降低,一氧化氮(NO)水平显著升高,差异有统计学意义(P<0.05);治疗后,治疗组患者血清氧化应激因子水平均显著优于对照组,组间比较有显著差异(P<0.05)。治疗后,两组患者白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平与同组治疗前数据相比较均显著降低,差异有显著性意义(P<0.05);治疗后,治疗组患者的IL-6、TNF-α、CRP水平均显著低于对照组,组间比较差异有显著性(P<0.05)。治疗后,两组患者血清胃动素(MTL)、胃泌素(GAS)水平与同组治疗前相比较均显著降低,差异有统计学意义(P<0.05);治疗后,治疗组患者的血清MTL、GAS水平明显低于对照组,组间有差异(P<0.05)。治疗后,治疗组幽门螺杆菌根除率、溃疡愈合率分别为90.00%、73.33%,分别高于对照组的76.66%、56.66%,组间有差异(P<0.05)。结论康复新液联合四联疗法治疗幽门螺杆菌阳性胃溃疡具有较好的临床疗效,可以减轻患者的炎性反应,改善氧化应激状态,对胃肠激素起到了较好的调节作用,安全性较高,值得在临床上借鉴。
Objective To study the effect of Kangfuxin Liquid combined with quadruple therapy in treatment of Helicobacter pylori positive gastric ulcer.Methods Patients(60 cases)with H.pylori positive gastric ulcer in Huaihe Hospital of Henan University from February 2019 to February 2020 were divided into control and treatment groups according to order of admission,and each group had 30 cases.Patients in the control group were given quadruple therapy:patients in the control group were po administered with Amoxicillin Capsules,twice daily,and patients in the control group were po administered with Clarithromycin Sustained Release Tablets,0.5 g/time,twice daily,and patients in the control group were po administered with Bismuth Potassium Citrate Granules,1 bag/time,4 bags daily,1 bag before three meals,and 1 bag 2 hours after dinner,and patients in the control group were po administered with Pantoprazole Sodium Enteric-Coated Capsules,40 mg/time,twice daily.Other drugs were stopped after 2 weeks of treatment,and only Pantoprazole Sodium Enteric-Coated Capsules were taken.Patients in the treatment group were po administered with Kangfuxin Liquid on the basis of the control group,10—15 mL/time,once daily.Patients in two groups were treated for 6 weeks.After treatment,the clinical efficacies were evaluated,and the serum levels of oxidative stress factors,inflammatory factors,and gastrointestinal hormone in two groups were compared.Results After treatment,the total effective rate of the treatment group(93.33%)was higher than that of the control group(76.67%),and there was difference between two groups(P<0.05).After treatment,the levels of MDA and LPO in two groups were significantly lower than those before treatment in the same group,and the level of NO in two groups was significantly higher than that before treatment(P<0.05).After treatment,the serum levels of oxidative stress factors in the treatment group were significantly better than those in the control group(P<0.05).After treatment,the levels of IL-6,TNF-α,and CRP in two groups were significantly lower than those before treatment(P<0.05).After treatment,the levels of IL-6,TNF-α,and CRP in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the levels of MTL and GAS in two groups were significantly lower than those before treatment(P<0.05).After treatment,the levels of MTL and GAS in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the H.pylori eradication rate and the ulcer healing rate in the treatment group were 90% and 73.33%,respectively,which were higher than those in the control group(76.66% and 56.66%),and there were differences between two groups(P<0.05).Conclusion Kangfuxin Liquid combined with quadruple therapy has clinical curative effect in treatment of H.pylori positive gastric ulcer,can reduce the inflammatory reaction of patients,improve the oxidative stress state,and play a better regulatory role in gastrointestinal hormones,with high safety,which is worthy of clinical reference.
作者
王雪艳
张旭东
潘海洋
WANG Xue-yan;ZHANG Xu-dong;PAN Hai-yang(Department of Gastroenterology,Huaihe Hospital of Henan University,Kaifeng 475000,China;Department of Ultrasound Medicine,Xuzhou Cancer Hospital,Xuzhou 221006,China)
出处
《现代药物与临床》
CAS
2021年第8期1613-1618,共6页
Drugs & Clinic
基金
国家自然科学基金资助项目(81700187)。
关键词
康复新液
四联疗法
阿莫西林胶囊
克拉霉素缓释片
枸橼酸铋钾颗粒
泮托拉唑钠肠溶胶囊
幽门螺杆菌阳性胃溃疡
氧化应激因子
炎性因子
胃肠道激素
Kangfuxin Liquid
quadruple therapy
Amoxicillin Capsules
Clarithromycin Sustained Release Tablets
Bismuth Potassium Citrate Granules
Pantoprazole Sodium Enteric-Coated Capsules
Helicobacter pylori positive gastric ulcer
inflammatory factor
oxidative stress factor
gastrointestinal hormone
