摘要
目的探讨小儿肺炎支原体肺炎(MPP)血清C反应蛋白(CRP)、降钙素原(PCT)、血沉(ESR)水平变化及其与MPP病情严重程度的关系。方法收集2017年6月~2019年5月于我院儿科接受诊治的138例MPP患儿临床资料行回顾性分析,根据治疗前病情严重程度分为重症组(62例)与轻症组(76例)。对比分析两组患儿治疗前后血清CRP、PCT、ESR水平,并分析其与MPP病情严重程度的关系;另根据治疗1个疗程后预后情况将MPP患儿分为预后良好组、预后不良组,比较两组血清CRP、PCT、ESR水平。结果治疗前重症组血清CRP、PCT、ESR、改良版英国医学研究委员会呼吸困难量表(mMRC)、临床肺部感染评分(CPIS)得分均显著高于轻症组(P<0.05),治疗后两组上述指标水平均显著低于治疗前(P<0.05),但重症组上述指标水平均显著高于轻症组(P<0.05);治疗前重症组CT肺正常密度容积百分比显著低于轻症组(P<0.05),治疗后两组CT肺正常密度容积百分比均显著高于治疗前(P<0.05),但重症组CT肺正常密度容积百分比显著高于轻症组(P<0.05);Spearman相关性分析显示血清CRP、PCT、ESR水平与MPP患儿CPIS、mMRC评分均呈正相关(P<0.05),但与CT肺正常密度容积百分比呈负相关(P<0.05);预后良好组血清CRP、PCT、ESR显著低于预后不良组(P<0.05);COX多因素分析显示血清CRP、PCT、ESR与预后密切相关(P<0.05)。结论血清CRP、PCT、ESR水平与MPP患儿病情严重程度呈正相关,并与预后情况有一定关联。
Objective To explore the changes in levels of serum C-reactive protein(CRP),procalcitonin(PCT)and erythrocyte sedimentation rate(ESR)in children with Mycoplasma pneumoniae pneumonia(MPP)and their relationship with MPP severity.Methods The clinical data of 138 MPP children who were diagnosed and treated in pediatrics department of the hospital from June 2017 to May 2019 were retrospectively collected.According to disease severity before treatment,they were divided into severe group(62 cases)and mild group(76 cases).The levels of serum CRP,PCT and ESR before and after treatment were compared and analyzed between the two groups.And their relationship with MPP severity was analyzed.According to the prognosis after 1 course of treatment,they were divided into good prognosis group and poor prognosis group.The levels of serum CRP,PCT and ESR were compared between the two groups.Results Before treatment,levels of serum CRP,PCT and ESR,scores of modified British Medical Research Council Dyspnea Scale(mMRC)and clinical pulmonary infection score(CPIS)in severe group were significantly higher than those in mild group(P<0.05).After treatment,the above-mentioned indexes in both groups were significantly decreased(P<0.05),which were still significantly higher in severe group than mild group(P<0.05).Before treatment,the percentage of CT normal lung density volume in severe group was significantly lower than that in mild group(P<0.05).After treatment,the percentage of CT normal lung density volume in both groups was significantly increased(P<0.05),which was significantly higher in severe group than mild group(P<0.05).Spearman correlation analysis showed that serum CRP,PCT and ESR levels were positively correlated with CPIS and mMRC scores in MPP children(P<0.05),while negatively correlated with the percentage of CT normal lung density volume(P<0.05).Serum CRP,PCT and ESR in good prognosis group were significantly lower than those in poor prognosis group(P<0.05).COX multivariate analysis showed that serum CRP,PCT and ESR were closely related to prognosis(P<0.05).Conclusion The levels of serum CRP,PCT and ESR are positively correlated with disease severity in MPP children,which are of certain correlation with their prognosis.
作者
李静
杨静容
李亚兰
黄华翠
LI Jing;YANG Jingrong;LI Yalan;HUANG Huacui(Department of Pediatrics,Xindu People's Hospital,Chengdu 610500,China;Department of Laboratory,Xindu People's Hospital,Chengdu 610500,China)
出处
《西部医学》
2021年第9期1374-1378,共5页
Medical Journal of West China
