摘要
我国是食管癌高发国。由于食管癌患者早期多无明显临床症状,确诊时多为中晚期,预后相对较差,已成为影响我国人民健康最常见的消化道恶性肿瘤之一。早期发现、早期诊断和早期治疗对于食管癌防治至关重要。发现早期食管癌尤其是食管癌癌前病变,并进行及时的干预治疗,能够降低高发区人群食管癌的发病率和死亡率。目前,临床上对于食管癌癌前病变的检测,主要是通过内窥镜染色技术,同时结合活检组织病理学探查。迄今,尚没有特异分子标志物在临床上应用。近年来,已有许多研究表明,一些分子标志物对于食管癌癌前病变有着潜在的临床诊断价值,本文就这一领域的研究进展进行综述。
China has a high incidence of esophageal cancer.Esophageal cancer has become one of the most common digestive tract malignant tumors that affect people’s health in China because of its no obvious clinical symptoms in early stage and relatively poor prognosis.So,early detection,early diagnosis and early treatment are very important for the prevention of esophageal cancer.Early detection of esophageal cancer,especially the precancerous lesion of esophageal cancer,and timely intervention and treatment can reduce the incidence and mortality of esophageal cancer in high-risk areas.At present,the detection of precancerous lesions of esophageal cancer in clinical practice depends mainly on endoscopic staining technique combined with biopsy histopathological exploration,but no specific molecular biomarkers have been applied clinically.In recent years,many studies have shown that some molecular markers have potential clinical diagnostic value for precancerous lesions of esophageal cancer.Thus,we would like to summarize the research progress in this field.
作者
许镒洧
林逸伟
彭裕辉
李荣耀
李恩民
XU Yi-wei;LIN Yi-wei;PENG Yu-hui;LI Rong-yao;LI En-min(Department of Clinical Laboratory,Cancer Hospital of Shantou University Medical College,Shantou,China,515041;The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area,Shantou University Medical College,Shantou,China,515041)
出处
《食管疾病》
2021年第3期227-231,共5页
Journal of Esophageal Diseases
关键词
食管癌
癌前病变
分子检测
esophageal cancer
precancerous lesions
molecular detection
