摘要
目的探究全视网膜光凝术(PRP)联合康柏西普玻璃体腔注射治疗非增殖性糖尿病视网膜病变的效果。方法选取本院非增殖性糖尿病视网膜病变患者84例,采用数字随机分组法将其分为对照组(n=42)与研究组(n=42)。对照组给予PRP治疗,研究组给予PRP联合康柏西普玻璃体腔注射治疗。比较两组患者的黄斑中心凹视网膜厚度(CMT)、眼内压(IOP)、视网膜神经纤维层(RNFL)厚度、平均光敏感度(MS)、临床疗效及并发症发生情况。结果治疗后,两组的CMT小于治疗前,且研究组小于对照组,差异具有统计学意义(P<0.05);两组治疗前、后的IOP、RNFL厚度、MS比较,差异无统计学意义(P>0.05)。研究组的治疗总有效率为95.24%,高于对照组的80.95%,差异具有统计学意义(P<0.05)。研究组的并发症总发生率为4.76%,低于对照组的19.05%,差异具有统计学意义(P<0.05)。结论PRP联合康柏西普玻璃体腔注射治疗非增殖性糖尿病视网膜病变,可提升临床疗效,降低并发症发生率,改善患者视网膜情况。
Objective To explore the effect of panretinal photocoagulation(PRP)combined with intravitreal injection of conbercept on non-proliferative diabetic retinopathy.Methods A total of 84 patients with non-proliferative diabetic retinopathy in our hospital were selected and divided into control group(n=42)and study group(n=42)by numerical random grouping method.The control group was treated with PRP,and the study group was treated with PRP combined with intravitreal injection of conbercept.The central macular thickness(CMT),intraocular pressure(IOP),retinal nerve fiber layer(RNFL)thickness,mean sensitivity(MS),clinical efficacy and complications were compared between the two groups.Results After treatment,the CMT in the two groups was smaller than that before treatment,and that in the study group was smaller than the control group,the difference was statistically significant(P<0.05);there were no significant differences in IOP,RNFL thickness and MS before and after treatment in the two groups(P>0.05).The total effective rate of treatment in the study group was 95.24%,which was higher than 80.95%in the control group,and the difference was statistically significant(P<0.05).The total incidence of complications in the study group was 4.76%,which was lower than 19.05%in the control group,and the difference was statistically significant(P<0.05).Conclusion PRP combined with intravitreal injection of conbercept in the treatment of non-proliferative diabetic retinopathy can improve the clinical efficacy,reduce the incidence of complications,and improve the retinal condition of patients.
作者
车红芳
张娟
赵文军
杨圆圆
郭奕
CHE Hongfang;ZHANG Juan;ZHAO Wenjun;YANG Yuanyuan;GUO Yi(Shaanxi Rehabilitation Hospital,Xi'an 710052,China)
出处
《临床医学研究与实践》
2021年第27期91-93,共3页
Clinical Research and Practice
