摘要
腹泻型肠易激综合征(IBS-D)是临床常见的一种肠功能紊乱性疾病,中医病机虽然有肝脾失调、肝旺脾虚、肝郁脾虚之别,但总与肝、脾两脏相关,且以肝郁脾虚最为常见。从病因病机、临床研究、作用机制研究三个方面综述肝郁脾虚型IBS-D的中医研究进展。以痛泻要方为代表,具有调肝理脾功效的中药方剂能很好地改善肝郁脾虚型IBS-D患者的腹痛、腹泻症状及心理、行为状态,进而提高患者的生活质量;在作用机制方面,中医药可能是通过调节脑-肠轴、内脏高敏感及相关离子转运等途径发挥治疗作用。
Diarrhea predominant irritable bowel syndrome(IBS-D)is a common intestinal dysfunction disease in clinic.Traditional Chinese medicine(TCM)pathogenesis may vary in different cases,for instance,liver-spleen imbalance,liver hyperactivity and spleen deficiency and liver depression and spleen deficiency,but it is the liver and spleen that are always affected and the most common syndrome is liver depression and spleen deficiency.The TCM research progress of IBS-D(liver depression and spleen deficiency syndrome)was reviewed from three aspects:etiology and pathogenesis,clinical research and mechanism of action.TCM prescription with the effect of regulating liver and spleen,represented by Tongxie Yaofang,can improve symptoms of abdominal pain and diarrhea,psychological and behavioral state of patients with IBS-D of liver depression and spleen deficiency syndrome,and then improve their quality of life.When it comes to the mechanism of action,the therapeutic effects of TCM can be realized by regulating brain-gut axis,visceral hypersensitivity and related ion transport.
作者
苗艳芳
王玉贤
MIAO Yanfang;WANG Yuxian(Digestive Center,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China)
出处
《上海中医药杂志》
2021年第7期91-94,共4页
Shanghai Journal of Traditional Chinese Medicine
基金
国家自然科学基金青年基金项目(81804003)
中国博士后科学基金项目(2017M610948)。
关键词
腹泻型肠易激综合征
肝郁脾虚证
痛泻要方
脑-肠轴
内脏高敏感
综述
diarrhea predominant irritable bowel syndrome
liver depression and spleen deficiency syndrome
Tongxie Yaofang
brain-gut axis
visceral hypersensitivity
review
