摘要
目的探讨慢性肾炎患者的血清HIF-1α、eGFR水平变化与疾病严重程度的相关性分析。方法选取2018年4月至2020年3月于本院就诊的慢性肾炎患者资料,将符合标准的120例纳入研究,列为观察组。根据慢性肾脏疾病(CKD)分期将观察组患者分为CKD1~2期组和CKD3~5期组。选取同时间段体检或就诊的肾功能正常患者资料75例,作为对照组。比较观察组和对照组患者的一般资料和实验室检查结果,包括年龄、性别、体重指数、24h尿蛋白和平均动脉压等;比较两组患者的血清指标水平,包括血清低氧诱导因子α(HIF-1α)、转化生长因子(TGF-β)、结缔组织生长因子(CTGF)和白细胞介素-6(IL-6)和估算肾小球滤过率(eC-FR)水平。结果观察组患者的年龄、24h尿蛋白、血尿酸、血清肌酐和平均动脉压均高于对照组(P<0.001);观察组患者的HIF-1α、转化生长因子β(TGF-β)、结缔组织生长因子(CTGF)和白细胞介素-6(IL-6水平)均高于对照组(P<0.001),eGFR水平低于对照组(P<0.001);观察.组CKD1~2期患者的HIF-1α、TGF-β、CTGF和IL-6水平均明显低于观察组CKD3~5期患者(P<0.001),eGFR水平明显高于观察组CKD3~5期患者(P<0.001)。观察组患者的HIF-1α、TGF-β、CTGF和IL-6水平与eGFR水平呈显著负相关(P<0.001),与CKD和平均动脉压呈显著正相关(P<0.001)。结论慢性肾炎患者血清HIF-1α水平异常升高,eGFR水平异常降低,其中HIF-1α水平与疾病严重程度呈显著正相关。
Objective To explore the correlation between the changes of serum HIF-1α and eGFR levels in patients with chronic nephritis and the severity of the disease.Methods Data of pa-tients with chronic nephritis treated in our hospital from April 2018 to March 2020 were selected,and 120 cases meeting the criteria were included in the observation group.According to the stage of chronic kidney disease(CKD),the observation group was divided into CKD1-2 stage group and CKD3-5 stage group.The data of 75 patients with normal renal function who had physical examination or treatment at the same time period were selected as the control group.General information and laboratory results were compared between the two groups,including age,sex,body mass index,24 h urinary protein and mean arterial pressure.Serum levels of hypoxia-inducing factor α(HlF-1α),transforming growth fac-tor(TGF-β),connective tissue growth factor(CTGF),interleukin-6(IL6)and glomerular filtration rate(eGFR)were compared between the two groups.Results The age,24 h urine protein,blood u-ric acid,serum creatinine and mean arterial pressure of the observation group were significantly higher than those of the control group,(P<0.001).The levels of HIF-1α,TGF-β,CTGF and IL-6 in the observation group were significantly higher than those in the control group(P<0.001),and the eGFR.levels were significantly lower than those in the control group(P<0.001).The levels of HIF-1α,TGF-β,CTGF and IL-6 in patients with CKD1-2 stage in observation group were significantly lower than those in CKD3-5 stage in observation group(P<0.001),and eGFR levels were significantly higher than those in observation group with CKD3-5 stage patients(P<0.001).The levels of HIF-1α,TGF-β,CTGF and IL-6 in the observation group were significantly negatively correlated with eG-FR levels(P<0.001),and significantly positively correlated with CKD and mean arterial pressure(P<0.001).Conclusions The serum HIF-la level of patients with chronic nephritis is abnormally in-creased,and the eGFR level is abnormally decreased.Among them,the HIF-1x level is significantly positively correlated with the severity of the disease.
作者
吴东
杨山珊
张庆红
史秀岩
Wu Dong;Yang Shanshan;Zhang Qinghong;Shi Xiuyan(Department of Nephrology,Taihe Hospital of Shiyan City,Shiyan 442000,China)
出处
《国际泌尿系统杂志》
2021年第5期899-902,共4页
International Journal of Urology and Nephrology
关键词
肾小球肾炎
低氧诱导因子1Α
肾小球滤过率
Glomerulonephritis
Hypoxia-Inducible Factor 1α
Glomeruar Filtrationrate
