摘要
目的探讨氨氯地平阿托伐他汀钙片对高血压合并冠心病患者血压水平及心功能的影响。方法86例高血压合并冠心病患者,随机分为对照组和观察组,各43例。对照组采取阿托伐他汀钙片治疗,观察组采取氨氯地平阿托伐他汀钙片治疗。比较两组患者临床疗效以及治疗前后血压与心功能指标。结果观察组治疗总有效率90.7%高于对照组的74.4%,差异具有统计学意义(χ^(2)=3.957,P=0.047<0.05)。治疗后,两组收缩压(SBP)、舒张压(DBP)、心肌肌钙蛋白T(cTnT)、孤独G蛋白偶联受体配体(Apelin)均低于本组治疗前,且观察组SBP(123.7±6.0)mm Hg(1 mm Hg=0.133 kPa)、DBP(68.9±5.0)mm Hg、cTnT(0.03±0.01)μg/L、Apelin(1.5±0.3)μg/L均低于对照组的(138.2±6.9)mm Hg、(76.3±5.6)mm Hg、(0.04±0.01)μg/L、(1.8±0.4)μg/L,差异均具有统计学意义(P<0.05)。结论氨氯地平阿托伐他汀钙片治疗高血压合并冠心病患者可有效降低血压水平并改善心功能,值得推广。
Objective To discuss the effect of amlodipine besylate and atorvastatin calcium tablets on blood pressure and cardiac function in patients with hypertension and coronary heart disease.Methods A total of 86 patients with hypertension and coronary heart disease were randomly divided into control group and observation group,with 43 cases in each group.The control group was treated with atorvastatin calcium tablets,and the observation group was treated with amlodipine besylate and atorvastatin calcium tablets.The clinical efficacy,blood pressure level and cardiac function before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 90.7%,which was higher than 74.4%in the control group,and the difference was statistically significant(χ^(2)=3.957,P=0.047<0.05).After treatment,the systolic blood pressure(SBP),diastolic blood pressure(DBP),cardiac troponin T(cTnT)and orphan G proteincoupled receptor ligand(Apelin)of the two groups were lower than those before treatment,and SBP(123.7±6.0)mm Hg(1 mm Hg=0.133 kPa),DBP(68.9±5.0)mm Hg,cTnT(0.03±0.01)μg/L,and Apelin(1.5±0.3)μg/L in the observation group were lower than(138.2±6.9)mm Hg,(76.3±5.6)mm Hg,(0.04±0.01)μg/L and(1.8±0.4)μg/L in the control group.All the differences were statistically significant(P<0.05).Conclusion Amlodipine besylate and atorvastatin calcium tablets can effectively reduce blood pressure and improve cardiac function in patients with hypertension and coronary heart disease,and it is worth promoting.
作者
吕国飞
LYU Guo-fei(People’s Hospital of Jianchang County,Huludao 125300,China)
出处
《中国实用医药》
2021年第26期107-109,共3页
China Practical Medicine
关键词
氨氯地平阿托伐他汀钙片
高血压
冠心病
血压
心功能
Amlodipine besylate and atorvastatin calcium tablets
Hypertension
Coronary heart disease
Blood pressure
Cardiac function
