摘要
目的探讨热疗联合TC化疗方案对晚期卵巢癌患者糖类抗原125(CA125)水平及肿瘤直径的影响。方法采用前瞻性随机试验方法,选取78例晚期卵巢癌患者作为研究对象,采用交替分组法将其分为A组和B组,各39例。A组采用TC化疗方案治疗,B组在A组基础上联合热疗。治疗5个月后,比较2组临床疗效,对比2组治疗前、治疗5个月的肿瘤直径、CA125水平,并比较2组治疗期间不良反应。结果治疗5个月后,B组总缓解率高于A组,差异有统计学意义(P<0.05)。2组治疗5个月后的肿瘤直径均小于治疗前,且B组小于A组,差异有统计学意义(P<0.05)。2组治疗5个月后CA125水平均低于治疗前,且B组低于A组,差异有统计学意义(P<0.05)。B组胃肠道反应、白细胞降低、肝肾功能损伤发生率均低于A组,差异有统计学意义(P<0.05)。结论热疗联合TC化疗方案可有效缓解晚期卵巢癌患者病情,缩小肿瘤直径,降低CA125水平,且不良反应较小,值得推广。
Objective To investigate the effect of thermotherapy combined with TC chemotherapy regimen on carbohydrate antigen 125(CA125)level and tumor diameter in patients with advanced ovarian cancer.Methods A prospective randomized trial was conducted to select 78 patients with advanced ovarian cancer as the research subjects,the alternating grouping method was used to divide them into group A and group B,with 39 cases in each group.Group A was treated with TC chemotherapy regimen,group B was combined with thermotherapy on the basis of group A,after 5 months of treatment,the clinical efficacy of the 2 groups was compared,the tumor diameter and CA125 level were compared between the 2 groups before and after 5 months of treatment,and the adverse reactions during treatment were compared between the 2 groups.Results After 5 months of treatment,the total remission rate in group B was higher than that in group A,with a statistical significant difference(P<0.05).The tumor diameter of 2 groups after 5 months of treatment was lower than that before treatment,and group B was lower than group A,with statistical significant differences(P<0.05).After 5 months of treatment,CA125 levels in 2 groups were lower than those before treatment,and group B was lower than group A,with statistical significant differences(P<0.05).The incidence of gastrointestinal reaction,leukopenia,liver and kidney function damage in group B was lower than that in group A,with a statistical significant difference(P<0.05).Conclusion Thermotherapy combined with TC chemotherapy regimen can effectively alleviate the condition of patients with advanced ovarian cancer,reduce the tumor diameter and reduce the level of CA125,and the adverse reactions are fewer,which is worthy of promotion.
作者
曹士红
CAO Shihong(Zhengzhou People’s Hospital,Zhengzhou,450000)
出处
《实用癌症杂志》
2021年第9期1494-1496,共3页
The Practical Journal of Cancer
关键词
卵巢癌
热疗
TC化疗方案
糖类抗原125
肿瘤直径
Ovarian cancer
Thermotherapy
TC chemotherapy regimen
Carbohydrate antigen 125
Tumor diameter
