摘要
轮状病毒是引起儿童肠道感染的最重要的病原,除造成胃肠道症状外还可通过病毒血症和呼吸道传播途径侵袭脑、肝脏、肺、心脏、肾脏等器官,引起相应病症。本研究针对轮状病毒肠道外感染所导致的中枢神经系统、肝脏、呼吸系统、心脏损伤及1型糖尿病的发病机制、实验室诊断、临床表现等进行系统阐述,为肠道外感染机制的探索提供参考。
Rotavirus is the most important pathogen of intestinal infections in children,often causing gastrointestinal symptoms.Rotavirus infects the brain,liver,lungs,heart,kidneys and other organs,causing a series of systemic diseases,through viremia and possible respiratory transmission.However,the mechanism of extra-intestinal infection is not yet clear,further study is still needed.This paper summarizes the pathogenesis,laboratory diagnosis and clinical manifestations of central nervous system damage,liver damage,type 1 diabetes,respiratory system damage and heart damage caused by extra intestinal infection of rotavirus to provide help for the exploration of the mechanism of extra-intestinal infection of rotavirus.
作者
范佳欣
李丹地
Fan Jiaxin;Li Dandi(Key Laboratory of Medical Viruses and Viral Diseases of National Health Commission,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China)
出处
《疾病监测》
CAS
CSCD
北大核心
2021年第8期785-788,共4页
Disease Surveillance
基金
国家自然科学基金(No.21934005,No.81601813)
国家科技重大专项(No.2018ZX10201002,No.2018ZX10711–001)。
关键词
轮状病毒
肠道外感染
发病机制
实验室诊断
临床表现
Rotavirus
Extraintestinal infection
Pathogenesis
Laboratory diagnosis
Clinical manifestation
