摘要
目的观察细胞角蛋白7(CK7)在食管鳞状细胞癌中的表达及其与预后的关系。方法采用免疫组化ELPS法检测512例食管鳞状细胞癌中CK7的表达,分析其表达与临床病理特征及患者预后的关系。结果512例食管鳞状细胞癌中CK7蛋白阳性率为24.6%,CK7表达与肿瘤分化差、淋巴结转移和临床分期较晚相关(P<0.05)。生存分析显示,CK7阳性患者的无瘤生存期(disease free survival,DFS)和总生存期(overall survival,OS)较短(DFS:P=0.016;OS:P=0.020)。多因素生存分析显示,pTNM分期是影响患者预后的独立危险因素。进一步分析发现,在Ⅰ+Ⅱ期食管鳞状细胞癌中,CK7阳性患者的DFS和OS较短(DFS:P=0.047;OS:P=0.023),Ⅲ+Ⅳ期食管鳞状细胞癌中,CK7阳性患者的DFS和OS与CK7阴性患者相比,差异无显著性(DFS:P=0.631;OS:P=0.824)。结论CK7阳性食管鳞状细胞癌可能存在较高的恶性程度。在Ⅰ+Ⅱ期食管鳞状细胞癌中,CK7表达与患者预后差相关,此发现有助于对这部分患者进行预后的危险度分级。
Purpose To evaluate the expression of cytokeratin 7(CK7)in esophageal squamous cell carcinoma(ESCC)and its prognostic significances.Methods The expression of CK7 in 512 cases of esophageal squamous cell carcinoma was detected by immunohistochemical ELPS method,and its relationship with the clinical features and prognosis was assessed.Results CK7 was expressed in 24.6%ESCC patients.And CK7 expression was associated with poor tumor differentiation,more lymph node metastases and higher pTNM stages(P<0.05).Survival analysis showed that CK7 expression was significantly correlated with disease free survival(DFS,P=0.016)and overall survival(OS,P=0.020).The results of Cox multivariate regression analysis showed that pTNM stage was an independent prognostic factor.Further analysis found CK7 expression was a significant predictor of worse DFS and OS in stageⅠ+ⅡESCC(DFS P=0.047,OS P=0.023),but not in stageⅢ+ⅣESCC(DFS P=0.631,OS P=0.824).Conclusion CK7 expression in ESCC might be associated with higher degree of malignancy.In stageⅠ+ⅡESCC patients,CK7 expression was significantly associated with poorer survival,which would help to identify high-risk patients.
作者
张磊
蒋冬先
黄洁
栾丽娟
管瑛瑛
徐磊
宿杰阿克苏
侯英勇
ZHANG Lei;JIANG Dong-xian;HUANG Jie;LUAN Li-juan;GUAN Ying-ying;XU Lei;SUJIE Akesu;HOU Ying-yong(Department of Pathology,Zhongshan Hospital,Fudan University,Shanghai 200032,China)
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2021年第7期814-818,共5页
Chinese Journal of Clinical and Experimental Pathology
基金
国家自然科学基金(81702372)
上海市自然科学基金(18ZR1406800)
上海市临床专科建设项目(shslczdzk01302)。
关键词
食管肿瘤
鳞状细胞癌
CK7
预后
免疫组织化学
esophageal neoplasm
squamous cell carcinoma
CK7
prognosis
immunohistochemistry
