摘要
滤泡辅助性T细胞淋巴瘤(T-FHCL)是一种外周T细胞淋巴瘤,对它的认识几十年来一直在不断发展,世界卫生组织2017年分类将其分为三个亚类别。由于T-FHCL常有误导性的组织病理表现和未完全阐明的发病机制,其诊断具有挑战性,通常需要进行一系列多方面的评估,特别是对于血管免疫母细胞性T细胞淋巴瘤(三个亚类中最常见)。分子生物学领域的最新进展已解开T-FHCL的基因组景观,其发生的潜在机制,尤其是其独特的微环境发育,现在也得到了更好的理解。在该篇评论中,不仅总结了T-FHCL的病理特征、更新的诊断标准和分类,而且讨论了T-FHCL分子研究的最新进展及其在诊断和疾病分类中的应用。
T-follicular helper cell lymphoma(T-FHCL)is a type of peripheral T-cell lymphoma.The understanding of T-FHCL has been evolving over the course of several decades,and it was classified into three subcategories by the World Health Organization in 2017.Because T-FHCL often has misleading histopathological manifestations and incompletely clarified pathogenesis,its diagnosis is challenging and usually requires a series of multifaceted evaluations,especially for angioimmunoblastic T-cell lymphoma(the most common of the three subcategories).Along with recent advances in the field of molecular biology,the genomic landscape of T-FHCL has been unraveled,and the mechanism underlying its lymphomagenesis,especially the development of its unique microenvironment,is now better understood.In this commentary,we not only summarize the pathological features,the updated diagnostic criteria,and classification of T-FHCL,but also discuss the latest advances in the molecular study of T-FHCL and its application in diagnosis and disease classification.
作者
赵月
Jenna McCracken
王恩第
ZHAO Yue;Jenna McCracken;WANG En-di(Department of Pathology,First Affiliated Hospital and College of Basic Medical Sciences,China Medical University,Shenyang 110001,China;Department of Pathology,Duke University School of Medicine,Durham,NC 27710,USA)
出处
《中国临床新医学》
2021年第9期852-860,共9页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
