摘要
目的:观察新活素治疗伴发焦虑、抑郁慢性心力衰竭(CHF)患者的疗效。方法:2019年10月-2020年6月收治CHF患者160例,根据焦虑、抑郁自评量表评分结果分为对照组、焦虑组、抑郁组及焦虑抑郁组。四组患者在常规抗心力衰竭治疗基础上给予新活素治疗,观察治疗效果。结果:新活素治疗后,四组患者脑钠利肽前体(Pro-BNP)水平均下降;对照组和焦虑组治疗前后比较,差异有统计学意义(P<0.01,P<0.05);抑郁组和焦虑抑郁组治疗前后比较,差异无统计学意义(P>0.05)。对照组和焦虑组治疗后Pro-BNP水平比较,差异无统计学意义(P>0.05),对照组、焦虑组与抑郁组比较,差异有统计学意义(P<0.05);对照组、焦虑组与焦虑抑郁组比较,差异有统计学意义(P<0.05)。焦虑抑郁组Pro-BNP与心脏彩超各参数情况,与PA呈正相关(r=0.434,P<0.01),与EF、FS呈负相关(r=-4.414,P<0.05;r=-0.625,P<0.01)。结论:新活素治疗CHF患者伴发抑郁的疗效不明显,这可能与其心力衰竭病理生理机制不同有关。
Objective:To observe the therapeutic effect of Xinhuosu on chronic heart failure(CHF)patients with anxiety and depression.Methods:From October 2019 to June 2020,160 patients with CHF were selected,they were divided into the control group,the anxiety group,the depression group,and the anxiety and depression group according to the scores of the anxiety and depression self-rating scale.The four groups of patients were treated with Xinhuosu on the basis of conventional anti-heart failure treatment,and the therapeutic effect was observed.Results:Before and after Xinhuosu treatment,the pro-brain natriuretic peptide(Pro-BNP)levels of the four groups of patients decreased.The comparison between the control group and the anxiety group before and after treatment,the difference was statistically significant(P<0.01,P<0.05).There was no statistically significant difference between the depression group and the anxiety and depression group before and after treatment(P>0.05).After Xinhuosu treatment,the Pro-BNP levels of the four groups of patients decreased.There was no significant difference between the control group and the anxiety group(P>0.05).The differences were statistically significant when comparing the control and the anxiety groups with the depression group(P<0.05).There was statistically significant difference between the control group and anxiety group compared with the anxiety-depression group(P<0.05).The relationship between Pro-BNP and various parameters of cardiac color Doppler ultrasound in the anxiety and depression group:PA was positively correlated(r=0.434,P<0.01).It was negatively correlated with EF and FS(r=-4.414,P<0.05;r=-0.625,P<0.01).Conclusion:Xinhuosu is not effective in the treatment of CHF patients with depression,which may be related to the different pathophysiological mechanism of heart failure.
作者
周玉能
Zhou Yuneng(Department of Cardiology,the People's Hospital of Qingcheng District,Qingyuan City,Guangdong Province,Guangdong Qingyuan 511500)
出处
《中国社区医师》
2021年第28期32-33,共2页
Chinese Community Doctors
关键词
心力衰竭
新活素
焦虑
抑郁
Heart failure
Xinhuosu
Anxiety
Depression
