摘要
目的:分析冠状动脉临界病变患者外周血血小板与淋巴细胞比值(PLR)与冠状动脉斑块易损性的相关性。方法:2018年6月-2020年6月收治冠状动脉临界病变患者120例,在患者入院时行血常规检查明确PLR,并通过血管内超声对冠状动脉内斑块形成状况及其组织成分予以测定,分析PLR与冠状动脉斑块易损性的相关性,同时通过ROC曲线在冠状动脉斑块易损性预测中对PLR的应用价值予以评估。结果:多因素线性分析得出,年龄、吸烟、糖尿病、PLR、低密度脂蛋白胆固醇、超敏C反应蛋白、糖化血红蛋白升高为危险因素,服用抗糖尿病药物为保护因素;冠状动脉斑块中脂质体积占比与PLR呈正相关(P<0.05),而纤维体积占比与PLR呈负相关(P<0.05)。ROC曲线分析得出,在冠状动脉斑块易损性预测方面,敏感度和特异度分别为76.09%、74.32%。结论:冠状动脉临界病变患者PLR与冠状动脉斑块易损性之间存在独立线性关系,可能成为该疾病患者冠状动脉斑块易损性预测的简易指标。
Objective:To explore the correlation between ratio of platelet to lymphocyte in peripheral blood(PLR)and coronary plaque vulnerability in patients with borderline coronary artery disease.Methods:From June 2018 to June 2020,120 patients with borderline coronary artery disease were selected,at the time of admission,blood routine examination was performed to confirm PLR,the plaque formation and tissue composition in coronary artery were measured by intravascular ultrasound,we analyzed the correlation between PLR and coronary plaque vulnerability,at the same time,the ROC curve was used to evaluate the application value of PLR in the prediction of coronary plaque vulnerability.Results:Multivariate analysis showed that age,smoking,diabetes,PLR,low density lipoprotein cholesterol,high sensitivity C reactive protein and glycosylated hemoglobin were risk factors,taking antidiabetic drugs was protective factor.The proportion of lipid volume in coronary plaque was positively correlated with PLR(P<0.05),the proportion of fiber volume was negatively correlated with PLR(P<0.05).ROC curve analysis showed that,in the prediction of coronary plaque vulnerability,the sensitivity and specificity were 76.09%and 74.32%respectively.Conclusion:There is an independent linear relationship between PLR and coronary plaque vulnerability in patients with borderline coronary artery disease,it may be a simple index to predict the vulnerability of coronary plaque in patients with this disease.
作者
蔡惜莲
Cai Xilian(Dongjiao Town Central Health Center of Wenchang City,Hainan Wenchang 571300)
出处
《中国社区医师》
2021年第28期108-109,112,共3页
Chinese Community Doctors
关键词
冠状动脉临界病变
外周血血小板与淋巴细胞比值
冠状动脉斑块易损性
相关性
预测价值
Coronary artery borderline lesions
The ratio of platelet to lymphocyte in peripheral blood
Coronary plaque vulnerability
Relevance
Predictive value
