摘要
在过去的30年中,随着影像学技术的发展及人们保健意识的提升,甲状腺癌(thyroid carcinoma,TC)的检出率明显上升,TC成为常见的恶性肿瘤之一,其中又以甲状腺乳头状癌(papillary thyroid carcinoma,PTC)发病率最高,因其分化程度高,恶性程度低,预后明显优于其他系统恶性肿瘤。桥本甲状腺炎(Hashimoto thyroiditis,HT)是一种常见的甲状腺自身免疫性疾病,其患者血清中可检出抗甲状腺过氧化物酶抗体(antithyroid peroxidase antibody,TPOAb)和抗甲状腺球蛋白抗体(antithyroglobulin antibody,TgAb)等多种自身免疫性抗体。近年来,HT合并TC的发病率呈上升趋势,两者之间的相关性成为临床研究的热点。有研究提出HT相关抗体状态与PTC的发生及病情进展密切相关。明确两者间的联系并将其运用于临床工作中显得尤为重要。
In the past 30 years,with the development of imaging technology and the improvement of people’s health awareness,the detection rate of thyroid carcinoma(TC)has increased markedly.Thyroid cancer has become one of the common malignant tumors,among which the incidence of papillary thyroid carcinoma(PTC)is the highest.Because of its high degree of differentiation and low malignancy,its prognosis is significantly better than other systemic malignancies.Hashimoto thyroiditis(HT)is a common autoimmune disease of the thyroid,and various autoimmune antibodies such as antithyroid peroxidase antibody(TPOAb)and antithyroglobulin antibody(TgAb)can be detected in the serum of patients.In recent years,the incidence of HT with thyroid cancer has been rising,so the correlation between them has become a hot spot in clinical research.Studies have suggested that the related antibodies of HT is closely related to the occurrence and progression of PTC.It is particularly important to clarify the connection between them and apply it in clinical work.
作者
于博
赵文君
王慧芳
王瑞佳(综述)
刘静(审校)
YU Bo;ZHAO Wenjun;WANG Huifang;WANG Ruijia;LIU Jing(Department of Thyroid Surgery,First Clinical Medical College of Shanxi Medical University,Taiyuan 030001;Department of Surgery for Gastrointestinal Pancreatic Abdominal Wall and Hernia,Shanxi Provincial People’s Hospital,Taiyuan 030012;Department of Thyroid Surgery,First Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《临床与病理杂志》
CAS
2021年第9期2172-2179,共8页
Journal of Clinical and Pathological Research
基金
山西省社会发展基金(201903D321147)。
