摘要
目的:分析左西孟旦联合无创呼吸机治疗急性心肌梗塞合并急性左心衰患者的应用价值及不良反应率。方法:选择我院2019年1月-2021年1月急性心肌梗塞合并急性左心衰者共98例,数字表随机分2组,对照组48例的患者给予米力农联合无创呼吸机治疗,观察组50例患者给予无创呼吸机联合左西孟旦。比较两组呼吸困难消失时间、住院时间、治疗前后患者二氧化碳分压、氧分压以及肺活量、峰值流速、第一秒用力呼气容积,并比较治疗前后彩色多普勒超声心功能指标、BNP、总有效率。结果:观察组呼吸困难消失时间、住院时间短于对照组,治疗后患者二氧化碳分压、氧分压以及肺活量、峰值流速、第一秒用力呼气容积、彩色多普勒超声心功能指标、BNP优于对照组,总有效率高于对照组,P<0.05。两组均无严重不良反应。结论:无创呼吸机联合左西孟旦对于急性心肌梗塞合并急性左心衰的治疗效果确切,可有效改善患者肺功能和呼吸情况、心功能,缩短治疗时间,安全性高,值得推广和应用。
Objective:To investigate the efficacy and adverse reaction of levosimendan combined with non-invasive mechanical ventilation in the treatment of acute myocardial infarction complicated with acute left heart failure.Methods:A total of 98 patients with acute myocardial infarction and acute left heart failure in our hospital between January 2019 and January 2021 were included and divided into two groups according to random number table.The control group(n=48)was were treated with milrinone combined with non-invasive mechanical ventilation,while the study group(n=50)were treated with levosimendan combined with non-invasive mechanical ventilation.The two groups were compared for the time to resolution of dyspnea,length of hospital stay,carbon dioxide partial pressure,oxygen partial pressure,vital capacity,peak flow rate,forced expiratory volume in one second,cardiac function indicators on color Doppler,and BNP level at baseline and after treatment,as well as the overall treatment response.Results:The time to resolution of dyspnea and the length of hospital stay were shorter in the study group than those in the control group.After treatment,the study group also showed greater improvements in carbon dioxide partial pressure,oxygen partial pressure,vital capacity,peak flow rate,forced expiratory volume in one second,cardiac function indicators on color Doppler,and BNP level,as well as higher treatment response,compared with the control group(P<0.05).There were no serious adverse reactions in the both groups.Conclusion:Non-invasive mechanical ventilation combined with levosimendan leads to definite efficacy in the treatment of acute myocardial infarction complicated with acute left heart failure,offering effective improvements in lung function,breathing and heart function,shorter treatment duration,and higher safety for the patients,and therefore warrants widespread use.
作者
李善敬
陈庞何
苏成标
李香
许锦荣
Li Shanjing;Chen Panghe;Su Chengbiao;Li Xiang;Xu Jinrong(Emergency Center,Second Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,Guangdong,China;Department of Cardiovascular Medicine,Second Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,Guangdong,China;Department of Preventive Healthcare,Second Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,Guangdong,China)
出处
《广州医科大学学报》
2021年第4期56-59,共4页
Academic Journal of Guangzhou Medical University
关键词
左西孟旦
无创呼吸机
急性心肌梗塞合并急性左心衰患者
应用价值
不良反应率
Levosimendan
Non-invasive ventilator
patients,acute myocardial infarction and acute left heart failure
Application value
Adverse reaction rate
